The effect of family support on self-reported adherence to ART among adolescents perinatally infected with HIV in Uganda: A mediation analysis.
The effect of family support on self-reported adherence to ART among adolescents perinatally infected with HIV in Uganda: A mediation analysis.
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DOI：
10.1002/jad.12157
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发表时间：
2023-06
影响因子：
3.8
通讯作者：
Ssewamala, Fred M
中科院分区：
文献类型：
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作者：
Nabunya, Proscovia;Samuel, Kizito;Ssewamala, Fred M
本研究考察了家庭支持如何影响乌干达围产期感染艾滋病毒的青少年自我报告坚持抗逆转录病毒治疗的机制。对702名青春期男孩和女孩（10-16岁）的纵向数据进行了分析。采用结构方程模型来评估家庭支持对依从性的直接、间接和总影响。结果显示，家庭支持对依从性有显著的间接影响（β = .112, 95%可信区间[CI]: 0.052-0.173, p < .001）。家庭支持通过挽救态度（β = 0.058, 95% CI: 0.008-0.108, p = 0.024）、与监护人沟通（β = 0.056, 95% CI: 0.012-0.100），以及家庭支持对依从性的总影响(β = 0.146 （95% CI: 0.032-0.259, p = 0.012）的具体间接影响均有统计学意义。调解对总效果的贡献率为76.7%。调查结果支持有助于促进家庭支持和加强感染艾滋病毒的青少年与其照顾者之间公开沟通的战略。
This study examined the mechanisms through which family support affects self-reported adherence to antiretroviral therapy among adolescents perinatally infected with HIV in Uganda. Longitudinal data from 702 adolescent boys and girls (10–16 years) were analyzed. Structural equation models were conducted to assess the direct, indirect, and total effects of family support on adherence. Results showed a significant indirect effect of family support on adherence (β = .112, 95% confidence interval [CI]: 0.052–0.173, p < .001). Specific indirect effects of family support through saving attitudes (β = .058, 95% CI: 0.008–0.108, p = .024), and communication with the guardian (β = .056, 95% CI: 0.012–0.100), p = .013), as well as the total effect of family support on adherence (β = .146 (95% CI: 0.032–0.259, p = .012), were statistically significant. Mediation contributed 76.7% of the total effects. Findings support strategies to help promote family support and strengthen open communication between adolescents living with HIV and their caregivers.
影响因子：
5.2
作者：
Krauss BJ;Letteney S;Okoro CN
通讯作者：
Okoro CN
影响因子：
3.7
作者：
Vreeman RC;Ayaya SO;Musick BS;Yiannoutsos CT;Cohen CR;Nash D;Wabwire D;Wools-Kaloustian K;Wiehe SE
通讯作者：
Wiehe SE