Insulin-sensitive obese children display a favorable metabolic profile
Insulin-sensitive obese children display a favorable metabolic profile
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DOI：
10.1007/s00431-012-1867-5
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发表时间：
2013-02-01
影响因子：
3.6
通讯作者：
Zdravkovic, Dragan
中科院分区：
文献类型：
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作者：
Vukovic, Rade;Mitrovic, Katarina;Zdravkovic, Dragan
关于代谢健康的肥胖现象的大部分知识都来自对成年人群的研究，迄今为止还没有识别这些个体的标准化标准。本研究的目的是确定通过胰岛素抵抗稳态模型评估（HOMA-IR）指数评估的保留的胰岛素敏感性是否与肥胖儿童有利的代谢特征相关。我们研究了 248 名儿童和青少年（150 名女性，98 名男性），年龄为 5.9-18.9 岁，患有饮食引起的肥胖（BMI > 95%）。根据 HOMA-IR 指数确定的胰岛素抵抗水平，将整个队列分为四分位数。 HOMA-IR 下四分位数的受试者被归类为胰岛素敏感组（ISG），而上四分位数的儿童被归类为胰岛素抵抗组（IRG）。 ISG 受试者的 HOMA-IR 值为千分之一货币符号2.75，而 IRG 组的儿童的 HOMA-IR 值为千分之一日元6.16。 ISG 组的受试者基础 β 细胞活性较低，空腹血糖受损或糖耐量受损的可能性较小。 ISG 受试者的 LDL 和总胆固醇、甘油三酯和转氨酶浓度较低，HDL 胆固醇水平较高。使用松田指数获得的结果与使用 HOMA-IR 获得的结果具有良好的相关性。结论：较低的 HOMA-IR 值与所研究儿童的良好代谢特征显着相关，这与成年人群的研究结果相关，并强调需要对儿童肥胖症中胰岛素抵抗的发展进行进一步的纵向研究。
Most of what is known about the metabolically healthy obese phenomenon is derived from studies in the adult population and no standardized criteria to identify these individuals exist to date. The aim of this study was to determine if the preserved insulin sensitivity evaluated by homeostatic model assessment of insulin resistance (HOMA-IR) index is associated with favorable metabolic profile in the obese children. We studied a group of 248 children and adolescents (150 female, 98 male), aged 5.9-18.9 years with diet-induced obesity (BMI > 95th percentile). The entire cohort was divided into quartiles based on levels of insulin resistance determined by HOMA-IR index. Subjects in the lower quartile of HOMA-IR were classified as insulin-sensitive group (ISG), whereas children in the upper quartile were categorized as insulin-resistant group (IRG). The ISG subjects had values of HOMA-IR a parts per thousand currency sign2.75 while the children from the IRG group had HOMA-IR a parts per thousand yen6.16. Subjects from ISG group had lower basal beta-cell activity and were less likely to have impaired fasting glucose or impaired glucose tolerance. Concentrations of LDL and total cholesterol, triglycerides, and transaminases were lower and HDL cholesterol levels were higher in ISG subjects. Findings obtained by the use of Matsuda index correlated well with the findings obtained by the use of HOMA-IR. Conclusion: Lower HOMA-IR values were significantly associated with favorable metabolic profile in studied children, which correlates with findings in the adult population and emphasizes the need for further, longitudinal studies of insulin resistance development in childhood obesity.