RANTES promoter genotype is associated with diabetic nephropathy in type 2 diabetic subjects
RANTES promoter genotype is associated with diabetic nephropathy in type 2 diabetic subjects
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DOI：
10.2337/diacare.26.3.892
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发表时间：
2003-03-01
期刊：
影响因子：
16.2
通讯作者：
Kawamori, R
中科院分区：
文献类型：
--
作者：
Nakajima, K;Tanaka, Y;Kawamori, R
目的-评估RANTES基因启动子多态性和RANTES受体（CCR 5基因）启动子多态性对日本2型糖尿病受试者糖尿病肾病的影响。研究设计和方法-共招募了616例日本2型糖尿病受试者。采用限制性片段长度多态性（PCR-RFLP）方法检测RANTES基因启动子区-28 C/G和-403 G/A多态性，以及CCR 5基因启动子区59029 G/A多态性。结果：RANTES-403基因型与肾病无关，而-28G等位基因在DN 2组中的频率显著较高（尿白蛋白尿肌酐比[ACR]大于或等于300 mg/g肌酐，血清肌酐[ACR]大于或等于300 mg/g肌酐）。
OBJECTIVE - To evaluate the effect of RANTES gene promoter polymorphism and RANTES receptor (CCR5 gene) promoter polymorphism on diabetic nephropathy in Japanese type 2 diabetic subjects.RESEARCH DESIGN AND METHODS - A total 616 Japanese subjects with type 2 diabetes were recruited. Polymorphisms of -28 C/G and -403 G/A in the RANTES gene promoter region, and of 59029 G/A in the CCR5 gene promoter region were detected by PCR-RFLP (restriction fragment length polymorphism). The association of these genotypes with nephropathy was analyzed.RESULTS - While the RANTES -403 genotype showed no association with nephropathy, the frequency of the -28G allele was significantly higher in the DN2 group (urinary albuminuria-to-creatinine ratio [ACR] greater than or equal to300 mg/g creatinine, serum creatinine