Optical coherence tomography today: speed, contrast, and multimodality
Optical coherence tomography today: speed, contrast, and multimodality
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DOI：
10.1117/1.jbo.19.7.071412
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发表时间：
2014-07-01
影响因子：
3.5
通讯作者：
Leitgeb, Rainer A.
中科院分区：
文献类型：
--
作者：
Drexler, Wolfgang;Liu, Mengyang;Leitgeb, Rainer A.
在过去的25年里，光学相干层析成像(OCT)已经发展成为最具创新性和最成功的平移光学成像技术之一，取得了巨大的经济效益和临床接受度。这在很大程度上是由于亚微米系统的分辨率提高了10倍，成像速度提高了50多万倍，达到每秒500多万次A扫描，后者是由本文综述的最先进的扫描源激光技术实现的。此外，OCT检测的并行化，如行场OCT和全场OCT，通过建立准静态扫描，进一步缩短了采集时间。除了技术上的改进外，OCT在功能和对比度增强方面的应用也已被研究，其中无标记血管成像显示出未来研究的巨大潜力。最后，回顾了与OCT结合的各种多模式成像模式，因为当OCT单独使用时，这些多模式实现可以协同地弥补OCT的基本限制。(C)作者。由SPIE在知识共享署名3.0未移植许可下发布。
In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.