De novo designed synthetic mimics of antimicrobial peptides.
De novo designed synthetic mimics of antimicrobial peptides.
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DOI：
10.1016/j.copbio.2008.10.013
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发表时间：
2008-12
影响因子：
7.7
通讯作者：
Tew, Gregory N.
中科院分区：
文献类型：
--
作者：
Scott, Richard W.;DeGrado, William F.;Tew, Gregory N.
抗菌肽是小型阳离子两亲物，在先天免疫系统中发挥重要作用。鉴于其广泛的特异性，它们似乎是理想的治疗剂。因此，在过去的十年中，人们对将它们开发为静脉注射抗生素产生了很大的兴趣。然而，事实证明利用基于肽的结构很难实现这一目标。虽然已经可以解决一些相对简单的问题，例如对蛋白水解的敏感性，但更严重的问题包括材料的费用、毒性、有限的功效和有限的组织分布。因此，我们开发了小型合成低聚物，旨在采用两亲性构象并表现出有效的抗菌活性，同时对宿主细胞无毒。一类合成的抗菌肽模拟物 (SMAMP) 正在开发为静脉注射抗生素
Antimicrobial peptides are small cationic amphiphiles that play an important role in the innate immune system. Given their broad specificity, they appear to be ideal therapeutic agents. As a result, over the last decade, there has been considerable interest in developing them as intravenously administered antibiotics. However, it has proven difficult to accomplish this goal with peptide-based structures. While it has been possible to solve some relatively simple problems such as susceptibility to proteolysis, more severe problems have included the expense of the materials, toxicity, limited efficacy, and limited tissue distribution. As a result, we developed small synthetic oligomers designed to adopt amphiphilic conformations and exhibit potent antimicrobial activity while being non-toxic to host cells. One class of these synthetic mimics of antimicrobial peptides (SMAMPs) is being developed as intravenous antibiotics
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影响因子：
15
作者：
Ilker, MF;Nüsslein, K;Coughlin, EB
通讯作者：
Coughlin, EB
影响因子：
15
作者：
Hamuro, Y;Schneider, JP;DeGrado, WF
通讯作者：
DeGrado, WF
影响因子：
3.9
作者：
Arnt, L;Tew, GN
通讯作者：
Tew, GN
影响因子：
4.1
作者：
Hodges, RS;Chen, Y;Mant, CT
通讯作者：
Mant, CT
影响因子：
--
作者：
Arnt, L;Nüsslein, K;Tew, GN
通讯作者：
Tew, GN