Cancellous bone volume and structure in the forearm: Noninvasive assessment with MR microimaging and image processing
Cancellous bone volume and structure in the forearm: Noninvasive assessment with MR microimaging and image processing
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DOI：
10.1148/radiology.206.2.9457185
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发表时间：
1998-02-01
期刊：
影响因子：
19.7
通讯作者：
Haddad, JG
中科院分区：
文献类型：
--
作者：
Wehrli, FW;Hwang, SN;Haddad, JG
目得：开发和应用一种方法，从桡骨远端的活体磁共振（MR）图像中推导松质骨结构参数，并评估这些参数作为骨质减少时椎体骨折状态的预测因子。材料和方法：MR图像在36名女性的桡骨远端，用三维部分翻转角自旋回波脉冲序列采集了137 × 137 × 500 μ m（3）体素大小的股骨干。根据椎体畸形和骨密度（BMD）将受试者分为健康或骨质疏松。在20名受试者中被评定为足够质量的图像采用适用于有限空间分辨率方案的方法进行处理。该方法依靠直方图反卷积来消除二值分割。松质骨结构被视为一个准规则的晶格，并与空间自相关分析，产生参数，量化小梁间距，邻接，和纵向排列的措施称为管状。结果：然而，BMD和任何结构参数都与椎体畸形分数无关，一个简单的功能，涉及管状和纵向间距预测畸形分数很好结论：桡骨远端松质骨的组织形态学参数可以从活体MR显微图像中获得，并且可以预测椎体畸形。
PURPOSE: To develop and apply a method for the derivation of cancellous bone architectural parameters from in vivo magnetic resonance (MR) images of the distal radius and to evaluate these parameters as predictors of vertebral fracture status in osteopenia.MATERIALS AND METHODS: MR images (137 x 137 x 500-mu m(3) voxel size) were acquired with a three-dimensional partial flip-angle spin-echo pulse sequence in the distal radius of 36 women. Subjects were classified as healthy or with osteoporosis on the basis of vertebral deformity and bone mineral density (BMD). Images rated as of adequate quality in 20 subjects were processed with a method that is applicable in the limited spatial resolution regime. The method relies on histogram deconvolution to Obviate binary segmentation. Cancellous bone structure was treated as a quasi-regular lattice and analyzed with spatial autocorrelation, yielding parameters that quantify intertrabecular spacing, contiguity, and a measure of longitudinal alignment called tubularity.RESULTS: Whereas neither BMD nor any of the structural parameters individually correlated significantly with vertebral deformity fraction, a simple function that involved tubularity and longitudinal spacing predicted deformity fraction well (r = .78, P < .005).CONCLUSION: Histomorphometric parameters characterizing cancellous bone in the distal radius can be derived from in vivo MR microimages and are predictive of vertebral deformity.