Response of circulating heat shock protein 70 and anti-heat shock protein 70 antibodies to catheter ablation of atrial fibrillation.
Response of circulating heat shock protein 70 and anti-heat shock protein 70 antibodies to catheter ablation of atrial fibrillation.
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DOI：
10.1186/1479-5876-11-49
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发表时间：
2013-02-23
影响因子：
7.4
通讯作者：
Bollmann A
中科院分区：
文献类型：
--
作者：
Kornej J;Reinhardt C;Kosiuk J;Arya A;Hindricks G;Adams V;Husser D;Bollmann A
本研究旨在探讨热休克蛋白70（HSP 70）和抗HSP 70抗体之间的关系以及房颤（AF）导管消融术后它们的变化和心律结果。我们研究了67例接受导管消融术的房颤患者（59±11岁，66%为男性，66%为孤立性房颤）。在导管消融术前和消融术后6个月，使用市售测定法定量循环HSP 70和抗HSP 70抗体水平。采用连续7天霍尔特心电图检测房颤复发。基线时，14例患者（21%）可检测到HSP 70，但临床或超声心动图变量与HSP 70的存在或水平之间无相关性。相反，阵发性AF患者（n=39）的抗HSP 70抗体（中位数[IQR]为43 [28 - 62] μg/ml）低于持续性AF患者（n=28; 53 [41 - 85] μg/ml，p=0.035）。使用多变量回归分析，AF类型是与抗HSP 70抗体相关的唯一变量（Beta=0.342，p=0.008）。6个月时，27例患者中存在HSP 70（41%，p<0.001 vs.基线）。类似地，存在抗HSP 70抗体的增加（48 [36 - 72]对57 [43 - 87] μg/ml，p<0.001）。HSP 70升高≥0.025 ng/ml（32 vs. 11%，p=0.038）或抗HSP 70升高≥2.5 μg/ml（26 vs. 4%，p=0.033）的患者AF复发率较高。HSP 70和抗HSP 70抗体可能-至少部分-与房颤的进展和导管消融术后的房颤复发有关。
This pilot study investigated the association between heat shock protein 70 (HSP70) and anti-HSP70 antibodies as well as their changes and rhythm outcome after atrial fibrillation (AF) catheter ablation. We studied 67 patients with AF (59±11 years, 66% male, 66% lone AF) undergoing catheter ablation. Circulating HSP70 and anti-HSP70 antibody levels were quantified using commercially available assays before and 6 months after catheter ablation. Serial 7-day Holter ECGs were used to detect AF recurrences. At baseline, HSP70 was detectable in 14 patients (21%), but there was no correlation between clinical or echocardiographic variables and the presence or the level of HSP70. In contrast, patients with paroxysmal AF (n=39) showed lower anti-HSP70 antibodies (median [IQR] of 43 [28 – 62] μg/ml) than patients with persistent AF (n=28; 53 [41 – 85] μg/ml, p=0.035). Using multivariable regression analysis, AF type was the only variable associated with anti-HSP70 antibodies (Beta=0.342, p=0.008). At 6 months, HSP70 was present in 27 patients (41%, p<0.001 vs. baseline). Similarly, there was an increase of anti-HSP70 antibodies (48 [36 – 72] vs. 57 [43 – 87] μg/ml, p<0.001). AF recurrence rates were higher in patients with HSP70 increase ≥0.025 ng/ml (32 vs. 11%, p=0.038) or anti-HSP70 increase ≥2.5 μg/ml (26 vs. 4%, p=0.033). HSP70 and anti-HSP70 antibodies may – at least in part – be associated in the progression of AF and AF recurrence after catheter ablation.
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影响因子：
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