Antileukemic activity of genistein, a major isoflavone present in soy products
Antileukemic activity of genistein, a major isoflavone present in soy products
复制标题
DOI：
10.1021/np070230s
复制
发表时间：
2008-01-01
影响因子：
5.1
通讯作者：
Momparler, Richard L.
中科院分区：
文献类型：
--
作者：
Raynal, Noeel J. -M.;Momparler, Louise;Momparler, Richard L.
大豆在传统医学中被用于治疗各种疾病，包括癌症。大豆中的异黄酮已在动物模型中显示出具有预防癌症的活性。然而，异黄酮对癌症的治疗作用仍不清楚。我们评估了染料木黄酮（1）（大豆中存在的一种主要异黄酮）的体外和体内抗白血病活性。我们观察到，它产生了剂量和时间依赖性的抗骨髓和淋巴白血病细胞系的抗肿瘤活性。此外，染料木黄酮治疗白血病细胞重新激活了因异常DNA甲基化而沉默的肿瘤抑制基因。富含染料木黄酮的饮食对小鼠产生了中度但显著的抗白血病作用。这种体内反应的有限程度可能是由于染料木黄酮在小鼠中的快速代谢失活。由于染料木黄酮在人体内的半衰期较长，富含大豆的饮食有可能产生在体外产生抗白血病活性的浓度范围内的这种染料木黄酮的血浆水平。
Soy has been used in traditional medicine for the treatment of various diseases, including cancer. The isoflavones present in soy have been shown in animal models to have cancer-preventing activity. However, the therapeutic effects of isoflavones against cancer are still unclear. We have evaluated the in vitro and in vivo antileukemic activity of genistein (1), a major isoflavone present in soy. We observed that it produced a dose- and time-dependent antineoplastic activity against myeloid and lymphoid leukemic cell lines. In addition, genistein treatment of the leukemic cells reactivated tumor suppressor genes that were silenced by aberrant DNA methylation. A genistein-enriched diet produced a moderate, but significant, antileukemic effect in mice. The limited extent of this in vivo response may have been due to the rapid metabolic inactivation of genistein in mice. Due to the longer half-life of genistein in humans, a soy-enriched diet has the potential to produce plasma levels of this isoflavone in the range of the concentrations used in vitro that produced an antileukemic activity.