Reduction of cortical GABAergic inhibition correlates with working memory impairment in recent onset schizophrenia
Reduction of cortical GABAergic inhibition correlates with working memory impairment in recent onset schizophrenia
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DOI：
10.1016/j.schres.2013.02.033
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发表时间：
2013-05
影响因子：
4.5
通讯作者：
S. Takahashi;S. Ukai;Asami Kose;T. Hashimoto;J. Iwatani;Masatoshi Okumura;T. Tsuji;K. Shinosaki
中科院分区：
文献类型：
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作者：
S. Takahashi;S. Ukai;Asami Kose;T. Hashimoto;J. Iwatani;Masatoshi Okumura;T. Tsuji;K. Shinosaki
背景精神分裂症早期存在认知功能障碍，GABA能功能障碍在这些认知功能障碍中的作用日益受到重视。在双脉冲经颅磁刺激(PpTMS)中，皮质GABA能抑制可以用短间隔皮质内抑制(SICI)来评估。本研究的目的是用ppTMS和神经心理测试仪检测新发精神分裂症患者皮层GABA能抑制与认知功能的关系。方法20例健康对照组(HC组)和20例病程小于3年的精神分裂症患者(SZ组)。所有受试者均接受SICI和皮层内促进(ICF)的ppTMS测量，SZ组采用简明精神分裂症日语版认知功能评定。我们检查了两组在ppTMS测量(静息运动阈值、SICI和ICF)方面的差异。在SZ组中，我们评估了SICI与认知表现的关系，以及SICI与年龄、病程、药物和精神病理的关系。结果SZ组的SICI显著低于HC组，并且SICI的降低与工作记忆任务的表现显著相关。HC组和SZ组在静息运动阈值和ICF方面无显著差异。SZ组SICI与年龄、病程、用药、精神病理等因素无明显相关性。结论新发精神分裂症患者大脑皮质GABA能抑制减少与工作记忆障碍有关。
BACKGROUNDCognitive impairments are present during the early course of schizophrenia, and the contribution of GABAergic dysfunction to these cognitive impairments has received increasing attention. Cortical GABAergic inhibition can be assessed using short-interval intracortical inhibition (SICI) in a paired-pulse transcranial magnetic stimulation (ppTMS). The aim of this study was to examine the relationship between cortical GABAergic inhibition and cognitive function in recent onset schizophrenia patients using ppTMS and a neuropsychological battery.METHODSThe subjects were 20 healthy controls (HC group) and 20 patients with schizophrenia whose duration of illness was less than three years (SZ group). All subjects underwent ppTMS measurements of SICI and intracortical facilitation (ICF), and cognitive performance of the SZ group was assessed using the Brief Assessment of Cognition in Schizophrenia Japanese-language version. We examined group differences in ppTMS measurements (resting motor threshold, SICI, and ICF). In the SZ group, we assessed the relationship between SICI and cognitive performance, and the relationships between SICI and age, duration of illness, medications, and psychopathology.RESULTSThe SZ group showed a significant reduction of SICI compared to the HC group, and demonstrated a significant correlation between the reduction of SICI and impaired performance of a working memory task. The HC and the SZ groups did not differ significantly in resting motor threshold and ICF. The SZ group did not show any significant correlations between SICI and age, duration of illness, medications, or psychopathology.CONCLUSIONSOur results suggest that the reduction of cortical GABAergic inhibition is related to impairment of working memory in patients with recent onset schizophrenia.