Improved quantitative myocardial T(2) mapping: Impact of the fitting model.
Improved quantitative myocardial T(2) mapping: Impact of the fitting model.
复制标题
DOI：
10.1002/mrm.25377
复制
发表时间：
2015-07
影响因子：
3.3
通讯作者：
Nezafat, Reza
中科院分区：
文献类型：
--
作者：
Akcakaya, Mehmet;Basha, Tamer A.;Weingaertner, Sebastian;Roujol, Sebastien;Berg, Sophie;Nezafat, Reza
关键词：
开发一种改进的 T2 准备 (T2prep) 平衡稳态自由进动 (bSSFP) 序列和信号松弛曲线拟合方法，用于心肌 T2 映射。心肌 T2 映射通常通过采集多个 T2prep bSSFP 图像并使用 2 参数松弛拟合估计体素 T2 值来执行。然而，2 参数拟合模型没有考虑 bSSFP 序列中成像脉冲的影响或 T2prep RF 脉冲中的其他缺陷，这可能会降低 T2 映射的稳健性。因此，我们提出了一种新颖的 T2 映射序列，该序列包含通过饱和准备获取的附加图像，模拟非常长的 T2prep 回波时间。这使得能够使用 3 参数拟合模型对 T2 图进行稳健估计，该模型捕获成像脉冲和其他缺陷的影响。进行体模成像以将使用所提出的 3 参数模型生成的 T2 图与传统的 2 参数模型以及自旋回波参考进行比较。对八名健康受试者进行体内成像，以比较不同的拟合模型。体模和体内数据表明，所提出的 3 参数模型拟合生成的 T2 值不会随着 T2prep 回波时间的不同选择而变化，并且与体模的参考值在统计上没有差异（对于三个 T2prep 回波，P = 0.10）。 2 参数模型表现出对 T2prep 回波时间选择的依赖性，并且与参考值显着不同（对于三个 T2prep 回波，P = 0.01）。所提出的成像序列与 3 参数模型相结合，可以精确测量心肌 T2 值，该值与 T2prep 回波时间的数量和持续时间无关。
To develop an improved T2 prepared (T2prep) balanced steady-state free-precession (bSSFP) sequence and signal relaxation curve fitting method for myocardial T2 mapping. Myocardial T2 mapping is commonly performed by acquisition of multiple T2prep bSSFP images and estimating the voxel-wise T2 values using a 2-parameter fit for relaxation. However, a 2-parameter fit model does not take into account the effect of imaging pulses in a bSSFP sequence or other imperfections in T2prep RF pulses, which may decrease the robustness of T2 mapping. Therefore, we propose a novel T2 mapping sequence that incorporates an additional image acquired with saturation preparation, simulating a very long T2prep echo time. This enables the robust estimation of T2 maps using a 3-parameter fit model, which captures the effect of imaging pulses and other imperfections. Phantom imaging is performed to compare the T2 maps generated using the proposed 3-parameter model to the conventional 2-parameter model, as well as a spin echo reference. In-vivo imaging is performed on eight healthy subjects to compare the different fitting models. Phantom and in-vivo data show that the T2 values generated by the proposed 3-parameter model fitting do not change with different choices of the T2prep echo times, and are not statistically different than the reference values for the phantom (P = 0.10 with three T2prep echoes). The 2-parameter model exhibits dependence on the choice of T2prep echo times and are significantly different than the reference values (P = 0.01 with three T2prep echoes). The proposed imaging sequence in combination with a 3-parameter model allows accurate measurement of myocardial T2 values, which is independent of number and duration of T2prep echo times.
登录
查看更多内容
影响因子：
3.3
作者：
Foltz, WD;Stainsby, JA;Wright, GA
通讯作者：
Wright, GA
影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
3.3
作者：
Huang, Teng-Yi;Liu, Yi-Jui;Poncelet, Brigitte P.
通讯作者：
Poncelet, Brigitte P.
影响因子：
24
作者：
Raman, Subha V.;Simonetti, Orlando P.;Ambrosio, Giuseppe
通讯作者：
Ambrosio, Giuseppe
影响因子：
3.3
作者：
BRITTAIN, JH;HU, BS;NISHIMURA, DG
通讯作者：
NISHIMURA, DG