EXCITATION OF PHASICALLY FIRING SUPRAOPTIC NEURONS DURING VASOPRESSIN RELEASE
EXCITATION OF PHASICALLY FIRING SUPRAOPTIC NEURONS DURING VASOPRESSIN RELEASE
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DOI：
10.1038/258080b0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
LEGROS, JJ
中科院分区：
文献类型：
--
作者：
HARRIS, MC;DREIFUSS, JJ;LEGROS, JJ
神经垂体激素加压素和催产素是在下丘脑视上核和室旁核的不同神经元中合成的，每种激素都可以独立释放。出血2和双侧颈总动脉阻断3无催产素释放后叶加压素，而4、5和分娩期间释放无后叶加压素的催产素。神经内分泌细胞产生全有或全无动作电位，这些动作电位传播到神经叶，在那里它们触发激素分泌。单个内分泌细胞的动作电位放电主要有两种类型：大多数在1-2个尖峰时连续和随机放电S−1，其余的具有阶段性的放电模式，爆发活动周期每10-60 S交替周期与静默周期8。
THE neurohypophysial hormones vasopressin and oxytocin are synthesised within separate neurones of the hypothalamic supraoptic and paraventricular nuclei1and each hormone can be liberated independently. Haemorrhage2and bilateral carotid occlusion3release vasopressin without oxytocin, whereas oxytocin is released without vasopressin during suckling4,5and parturition6. The neuroendocrine cells produce all-or-none action potentials which propagate to the neural lobe, where they trigger hormone secretion7. Action potential firing of individual endocrine cells falls into two principal categories: most fire continuously and randomly at 1–2 spikes s−1, while the rest have a phasic pattern of firing, periods of bursting activity alternating every 10–60 s with periods of silence8.