Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
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DOI：
10.1101/gad.12.4.473
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发表时间：
1998-02-15
影响因子：
10.5
通讯作者：
Orkin, SH
中科院分区：
文献类型：
--
作者：
Visvader, JE;Fujiwara, Y;Orkin, SH
转录因子SCL/tal-1对血细胞发育至关重要。虽然它也在血管内皮中表达，但SCL一直被认为是血管形成不可或缺的。通过对SCL-/-胚胎造血缺陷的转基因修复和对血管内皮细胞表达转基因标记的SCL-/- ES细胞嵌合体的分析，我们发现SCL在卵黄囊毛细血管网络形成复杂卵黄血管的血管重建中是必不可少的。这些发现确立了SCL在胚胎血管生成中的作用，并论证了SCL在胚胎血液细胞和血管细胞（推定成血管细胞的后代）中的关键功能。
The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium, SCL has been considered dispensable for vessel formation. Through transgenic rescue of hematopoietic defects of SCL-/- embryos and analysis of chimeras generated with SCL-/- ES cells tagged with a transgene expressed in vascular endothelial cells, we show that SCL is essential for angiogenic remodeling of the yolk sac capillary network into complex vitelline vessels. These findings establish a role for SCL in embryonic angiogenesis and argue for critical functions in both embryonic blood and vascular cells, the descendents of the presumptive hemangioblast.