Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh
Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh
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DOI：
10.1093/ajcn/85.5.1367
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发表时间：
2007-05-01
影响因子：
7.1
通讯作者：
Ahsan, Habibul
中科院分区：
文献类型：
--
作者：
Heck, Julia E.;Gamble, Mary V.;Ahsan, Habibul
背景资料：无机砷（InAs）代谢为甲基胂酸（MMA）和二甲基胂酸（DMA），这种甲基化促进尿砷排泄。以前的研究表明，人与更完整的甲基化，特点是更大的比例DMA和MMA和尿中的InAs的比例较小，有一个较低的风险，不良砷相关的健康outcomes.Objective：本研究的目的是研究是否有能力甲基化砷不同的营养摄入量。设计：参与者是1016名孟加拉国成年人，暴露于饮用水中的砷。营养素的摄入量进行了评估与验证的食物频率问卷。多元回归分析被用来检查协会的营养素与尿砷代谢profiles.Results：在多变量分析中，半胱氨酸，蛋氨酸，钙，蛋白质和维生素B-12的摄入量较高，与较低的百分比InAs和较高的比例MMA InAs在尿中。较高的烟酸（0 = 0.22，P = 0.02）和胆碱（β = 0.10，P = 0.02）的摄入量与较高的DMA-MMA比率，调整后的年龄，性别，吸烟，总尿砷，总能量intake.Conclusions：从目前的研究结果显示多种营养物质对砷甲基化的影响。特别是，这项研究强调了半胱氨酸，蛋氨酸，烟酸，维生素B-12和胆碱的饮食摄入量的潜在重要性，通过调节砷的代谢对健康的影响。
Background: Inorganic arsenic (InAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), and this methylation facilitates urinary arsenic excretion. Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes.Objective: The purpose of this study was to examine whether the capacity to methylate arsenic differs by nutrient intake. Design: Participants were 1016 Bangladeshi adults exposed to arsenic in drinking water. Nutrient intake was assessed with a validated food-frequency questionnaire. Multivariate regression analyses were used to examine associations of nutrients with urinary arsenic metabolite profiles.Results: In multivariate analyses, higher intakes of cysteine, methionine, calcium, protein, and vitamin B-12 were associated with lower percentages of InAs and higher ratios of MMA to InAs in urine. Higher intakes of niacin (0 = 0.22, P = 0.02) and choline (beta = 0.10, P = 0.02) were associated with higher DMA-to-MMA ratios, after adjustment for age, sex, smoking, total urinary arsenic, and total energy intake.Conclusions: Findings from the current study show the influence of multiple nutrients on arsenic methylation. In particular, this study highlights the potential importance of dietary intakes of cysteine, methionine, niacin, vitamin B-12, and choline on health effects of arsenic by modulating its metabolism.