Functional Characterization of the Cingulo-Opercular Network in the Maintenance of Tonic Alertness
Functional Characterization of the Cingulo-Opercular Network in the Maintenance of Tonic Alertness
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DOI：
10.1093/cercor/bhu072
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发表时间：
2015-09-01
期刊：
影响因子：
3.7
通讯作者：
D'Esposito, Mark
中科院分区：
文献类型：
--
作者：
Sadaghiani, Sepideh;D'Esposito, Mark
注意力控制背后的复杂处理架构需要描述不同控制相关大脑网络的功能作用。一个关键的组成部分是扣带-鳃盖（CO）网络，包括前扣带/鳃盖，背侧前扣带皮层和丘脑。由于该网络的普遍活动和与其他控制相关网络的频繁共同激活，其功能特别难以描述。我们以前认为这个网络是内在维持紧张性警觉的基础。在这里，我们测试了这一假设，分别操纵的需求，选择性注意和紧张性警觉的两个因素，连续音高歧视的范例。2个因素具有独立的行为效应。功能成像显示，当任务需要更多的紧张性警觉时，CO网络的活动和功能连接都会增加。相反，提高对音高的选择性注意力会增加背侧注意（DAT）网络的活动，但不会增加CO网络的活动。在所有参与者中，表现准确性与CO、DAT和额顶叶（FP）控制网络中的活动呈可分离的相关模式。这些结果支持紧张性警觉作为一氧化碳网络的基本功能。他们进一步将这一功能描述为维持认知能力以满足当前处理要求的努力过程。
The complex processing architecture underlying attentional control requires delineation of the functional role of different control-related brain networks. A key component is the cingulo-opercular (CO) network composed of anterior insula/operculum, dorsal anterior cingulate cortex, and thalamus. Its function has been particularly difficult to characterize due to the network's pervasive activity and frequent co-activation with other control-related networks. We previously suggested this network to underlie intrinsically maintained tonic alertness. Here, we tested this hypothesis by separately manipulating the demand for selective attention and for tonic alertness in a two-factorial, continuous pitch discrimination paradigm. The 2 factors had independent behavioral effects. Functional imaging revealed that activity as well as functional connectivity in the CO network increased when the task required more tonic alertness. Conversely, heightened selective attention to pitch increased activity in the dorsal attention (DAT) network but not in the CO network. Across participants, performance accuracy showed dissociable correlation patterns with activity in the CO, DAT, and fronto-parietal (FP) control networks. These results support tonic alertness as a fundamental function of the CO network. They further the characterization of this function as the effortful process of maintaining cognitive faculties available for current processing requirements.