Bone and fat - Old questions, new insights
Bone and fat - Old questions, new insights
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DOI：
10.1385/endo:23:2-3:183
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发表时间：
2004-03-01
期刊：
影响因子：
3.7
通讯作者：
Nuttall, ME
中科院分区：
文献类型：
--
作者：
Gimble, JM;Nuttall, ME
直到最近，脂肪组织被认为只是作为甘油三酯的储存库，并被降级为被动的内分泌作用。随着瘦素和其他脂肪因子的发现，脂肪组织现在被认为是全身代谢的积极参与者。本文重点介绍脂肪组织与骨代谢和分化之间存在的复杂关系。它探讨了塑造过去十年研究的范式，以及这些发现对未来的预测。特别注意的是多能成体干细胞群，驻留在骨骼和脂肪。这些成体干细胞对组织工程和再生医学的新兴领域至关重要。
Until recently, adipose tissue was considered to serve only as a triglyceride reservoir and was relegated to a passive endocrine role. With the discovery of leptin and other adipokines, adipose tissue is now recognized as an active participant in systemic metabolism. This review focuses on the complex relationship existing between adipose tissue and bone metabolism and differentiation. It explores the paradigms that have shaped the past decade's research and what these findings forecast for the future. Particular attention is given to the multipotent adult stem cell populations that reside within bone and fat. These adult stem cells have critical importance to the emerging field of tissue engineering and regenerative medicine.