MHCBN 4.0: A database of MHC/TAP binding peptides and T-cell epitopes.
MHCBN 4.0: A database of MHC/TAP binding peptides and T-cell epitopes.
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DOI：
10.1186/1756-0500-2-61
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发表时间：
2009-04-20
影响因子：
1.8
通讯作者：
Raghava GP
中科院分区：
文献类型：
--
作者：
Lata S;Bhasin M;Raghava GP
过去已经开发了许多包含关于MHC结合剂和非结合剂的信息的数据库，以帮助在免疫学、免疫信息学或疫苗设计领域工作的科学界。随着这些MHC结合和非结合肽的信息随着时间的推移而不断增长，因此需要保持数据库的更新。因此，为了向免疫学界提供最新的信息，我们需要定期维护和更新我们的数据库。在本文中，我们描述了数据库MHCBN的4.0更新版本。MHCBN是一个综合数据库，包含超过25，857个肽序列（1053个TAP结合肽），其与MHC或TAP分子的结合亲和力已通过实验测定。它是一个手动管理的数据库，其中的条目是从已发表的文献和现有的免疫学公共数据库中收集和编辑的。MHCBN有许多基于网络的工具，用于分析和检索信息，如抗原区域的映射，等位基因特异性数据集的创建，BLAST搜索，与MHC等位基因相关的各种疾病等。此外，所有条目都与主要数据库如SWISS-PROT，PDB等超链接，以提供超出MHCBN范围的信息。MHCBN的最新版本4.0比之前发布的版本1.1多了6080个条目。MHCBN数据库的更新旨在帮助免疫学家了解免疫系统，并为他们提供最新信息。我们认为，我们的数据库将补充现有的数据库，为科学界服务。
Many databases housing the information about MHC binders and non-binders have been developed in the past to help the scientific community working in the field of immunology, immune-informatics or vaccine design. As the information about these MHC binding and non-binding peptides continues to grow with the time and there is a need to keep the databases updated. So, in order to provide the immunological fraternity with the most recent information we need to maintain and update our database regularly. In this paper, we describe the updated version of 4.0 of the database MHCBN. MHCBN is a comprehensive database comprising over 25,857 peptide sequences (1053 TAP binding peptides), whose binding affinity with either MHC or TAP molecules has been assayed experimentally. It is a manually curated database where entries are collected & compiled from published literature and existing immunological public databases. MHCBN has a number of web-based tools for the analysis and retrieval of information like mapping of antigenic regions, creation of allele specific dataset, BLAST search, various diseases associated with MHC alleles etc. Further, all entries are hyper linked to major databases like SWISS-PROT, PDB etc. to provide the information beyond the scope of MHCBN. The latest version 4.0 of MHCBN has 6080 more entries than previously published version 1.1. MHCBN database updating is meant to facilitate immunologist in understanding the immune system and provide them the latest information. We feel that our database will complement the existing databases in serving scientific community.