Keeping the balance between proliferation and differentiation: the primary cilium.
Keeping the balance between proliferation and differentiation: the primary cilium.
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DOI：
10.2174/138920211795860134
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发表时间：
2011-06
期刊：
影响因子：
2.6
通讯作者：
Badano JL
中科院分区：
文献类型：
--
作者：
Irigoín F;Badano JL
初级纤毛是存在于人体中绝大多数细胞类型中的有丝分裂后的细胞器。近年来收集的大量数据表明，这种细胞器在许多细胞过程中发挥着至关重要的作用，包括机械和化学感觉以及对不同组织和器官的发育和维持至关重要的信号级联的转导。因此，纤毛目前被认为是细胞的触角，在细胞与其环境之间的间期发挥关键作用，整合了一系列刺激，以调节细胞的命运决定，包括细胞增殖，迁移和分化。重要的是，这种调节作用不仅是它们参与信号转导的结果，而且也是纤毛发生与细胞周期的紧密同步/调节以及单个纤毛蛋白在纤毛依赖和独立过程中的作用的结果。在这里，我们审查的作用，初级纤毛在细胞增殖和分化的调节，并说明如何提供这种知识的洞察力，了解纤毛功能障碍的表型后果。
Primary cilia are post-mitotic cellular organelles that are present in the vast majority of cell types in the human body. An extensive body of data gathered in recent years is demonstrating a crucial role for this organelle in a number of cellular processes that include mechano and chemo-sensation as well as the transduction of signaling cascades critical for the development and maintenance of different tissues and organs. Consequently, cilia are currently viewed as cellular antennae playing a critical role at the interphase between cells and their environment, integrating a range of stimuli to modulate cell fate decisions including cell proliferation, migration and differentiation. Importantly, this regulatory role is not just a consequence of their participation in signal transduction but is also the outcome of both the tight synchronization/regulation of ciliogenesis with the cell cycle and the role of individual ciliary proteins in cilia-dependent and independent processes. Here we review the role of primary cilia in the regulation of cell proliferation and differentiation and illustrate how this knowledge has provided insight to understand the phenotypic consequences of ciliary dysfunction.