Transfer function analysis of gender-related differences in cerebral autoregulation.
Transfer function analysis of gender-related differences in cerebral autoregulation.
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发表时间：
2005
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通讯作者：
Xue Wang;S. Krishnamurthy;Joyce Evans;D. Bhakta;Larry Justice;E. Bruce;A. Patwardhan
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作者：
Xue Wang;S. Krishnamurthy;Joyce Evans;D. Bhakta;Larry Justice;E. Bruce;A. Patwardhan
性别在心血管调节中的作用得到了广泛的研究，但性别之间脑自动调节(CA)的差异仍未得到深入研究。在这项研究中，我们使用光谱分析来分析10名男性和10名年龄匹配的女性在大脑自动调节方面的差异。受试者在仰卧位休息(20min)，然后被动地倾斜到70度头高位(30min)。在仰卧位的前10分钟，他们只呼吸室内空气(仰卧位对照)，而在仰卧位的第二个10分钟，他们呼吸室内空气或室内空气加5%二氧化碳(伪随机二进制序列，PRBS)(仰卧位PRBS)。在倾斜的前10分钟内，受试者呼吸室内空气或室内空气加5%二氧化碳的PRBS(倾斜PRBS)。在剩下的20分钟倾斜中，他们只呼吸室内空气(倾斜控制)。用Finapres和经颅多普勒无创记录血压(BP)和脑血流速度(CBFV)。计算平均BP和平均CBFV之间的一致性和传递函数。在仰卧位控制中，女性在0.03-0.10赫兹和0.22-0.31赫兹频率范围内的一致性(p<；0.05)和传递函数增益(p<；0.01)高于男性。倾斜时，男性在0.05-0.26赫兹范围内的一致性高于女性(P<；0.02)。虽然这些与性别相关的脑自动调节差异的原因尚不清楚，但我们的结果表明，在研究脑自动调节时，性别可能需要被考虑为一个因素。
Effects of gender in cardiovascular regulation are widely investigated, however differences in cerebral autoregulation (CA) between genders remains less explored. In the present study, we used spectral analysis to analyze differences in cerebral autoregulation between 10 men and 10 age-matched women. Subjects rested in a supine position (20 min) and then were passively tilted to a 70-degree head up tilt position (30 min). During the first 10 min of supine they breathed only room air (Supine Control) while during the second 10 min of supine they breathed room air or room air plus 5% CO2 in a Pseudo Random Binary Sequence (PRBS) (Supine PRBS). During the first 10 min of tilt, subjects breathed room air or room air plus 5% CO2 switched in a PRBS (Tilt PRBS). For the remaining 20 min of tilt, they breathed only room air (Tilt Control). Blood pressure (BP) and cerebral blood flow velocity (CBFV) were non-invasively recorded using Finapres and Transcranial Doppler. Coherence and transfer function between mean BP and mean CBFV were estimated. During Supine Control, women had higher coherence (p < 0.05) and transfer function gain (p < 0.01) within 0.03-0.10 Hz and 0.22-0.31 Hz than men. During tilt, coherence within 0.05-0.26 Hz were higher in men than in women (P < 0.02). Although the reasons for these gender-related differences in cerebral autoregulation remain unclear, our results suggest that in investigating cerebral autoregulation, gender may need to be considered as a factor.