Associations among circulating sex hormones, insulin-like growth factor, lipids, and mammographic density in postmenopausal women
Associations among circulating sex hormones, insulin-like growth factor, lipids, and mammographic density in postmenopausal women
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DOI：
10.1158/1055-9965.epi-04-0920
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发表时间：
2005-06-01
影响因子：
3.8
通讯作者：
McTiernan, A
中科院分区：
文献类型：
--
作者：
Aiello, EJ;Tworoger, SS;McTiernan, A
目的：多项研究表明，激素治疗的使用与乳房 X 光密度呈正相关。然而，很少有研究探讨内源性激素水平与乳房X线密度之间的关联。因此，我们评估了 88 名未接受激素治疗的超重、绝经后妇女的内源性激素、胰岛素样生长因子 (IGF) 和脂质与乳房 X 光密度的关系。方法：使用计算机辅助程序作为连续测量值评估密度百分比和致密面积。我们使用多元线性回归来评估性激素、IGF 和胆固醇与乳房 X 光密度的关联，并调整包括肥胖在内的混杂因素。我们根据激素治疗使用史（以前与从未）和激素治疗潜伏期（<5年与>=5年）进行分层评估。结果：在以前的激素治疗使用者中，乳房X线照相密度与雌酮（P = 0.01）、雌二醇（P = 0.003）、游离雌二醇（P = 0.004）、睾酮（P = 0.04）、游离睾酮的循环水平呈负相关。 (P = 0.02)、雄烯二酮 (P < 0.001)、脱氢表雄酮 (P = 0.01) 以及 IGF-I 与其结合蛋白的比率 (IGF-I/IGFBP-3；P = 0.04)。当我们将分析仅限于过去 5 年内使用过激素治疗的女性时，我们发现了类似的关联。我们还注意到，在以前的激素治疗使用者中，乳房X线照相密度与总胆固醇（P = 0.03）和低密度脂蛋白（P = 0.03）呈正相关。在从未使用过激素治疗的女性中没有发现任何关联。结论：这些结果表明，在以前接受过激素治疗的绝经后女性中，内源性激素与乳房X光密度之间存在负相关关系。这与激素治疗文献不一致，应在更大规模的研究中得到证实。
Objective: Hormone therapy use has been positively associated with mammographic density in several studies. However, few studies have examined the association between endogenous hormone levels and mammographic density. Therefore, we evaluated the relationship of endogenous sex hormones, insulin-like growth factor (IGF), and lipids with mammographic density in 88 overweight, postmenopausal women not taking hormone therapy.Methods: Percent density and dense area were evaluated as continuous measures using a computer-assisted program. We used multiple linear regression to evaluate the associations of sex hormones, IGF, and cholesterol with mammographic density, adjusting for confounders, including adiposity. We evaluated stratification by history of hormone therapy use (former versus never) and hormone therapy latency (< 5 versus >= 5 years).Results: Among former hormone therapy users, mammographic density was inversely associated with circulating levels of estrone (P = 0.01), estradiol (P = 0.003), free estradiol (P = 0.004), testosterone (P = 0.04), free testosterone (P = 0.02), androstenedione (P < 0.001), dehydroepiandrosterone (P = 0.01), and the ratio of IGF-I to its binding protein (IGF-I/IGFBP-3; P = 0.04). We found similar associations when we limited the analyses to women who had used hormone therapy within the past 5 years. We also noted positive associations of mammographic density with total cholesterol (P = 0.03) and low-density lipoprotein (P = 0.03) among former hormone therapy users. No associations were noted among women who had never used hormone therapy.Conclusions: These results suggest that there is an inverse relationship between endogenous sex hormones and mammographic density in postmenopausal women among former users of hormone therapy. This is not consistent with the hormone therapy literature and should be confirmed in larger studies.