Combined effects of physical activity, dietary isoflavones and 17β-estradiol on movement drive, body weight and bone mineral density in ovariectomized female rats
Combined effects of physical activity, dietary isoflavones and 17β-estradiol on movement drive, body weight and bone mineral density in ovariectomized female rats
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DOI：
10.1055/s-2006-931579
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发表时间：
2006-05-01
期刊：
影响因子：
2.7
通讯作者：
Diel, Patrick
中科院分区：
文献类型：
--
作者：
Hertrampf, Torsten;Degen, Gisela H.;Diel, Patrick
绝经期女性雌激素水平降低，伴有各种疾病，如潮热、抑郁、骨质疏松、体重增加和运动动力减少。在这项研究中，我们在动物模型中研究了体育锻炼、雌二醇替代和富含植物雌激素的饮食对骨密度、体重增加和运动驱动的综合影响。切除卵巢（OVX）的雌性Wistar大鼠分别饲喂富含异黄酮的饲料（IRD）或17 β -雌二醇（E-2）替代3个月。假手术大鼠（Sham）和给药的OVX动物作为对照。一半的动物有机会自愿跑轮。OVX大鼠的运动活动比Sham动物低8倍。E-2处理明显增加OVX大鼠的运动活性，而IRD不明显。在3个月期间，Sham动物的体重增加最低，OVX动物的体重增加率最高。与OVX动物相比，E-2处理也显著降低了体重的增加，但IRD没有。与Sham动物相比，OVX大鼠胫骨小梁区域的骨矿物质密度（BMD）明显降低。与IRD相比，与OVX动物相比，E-2替代导致该区域的骨密度保护。我们的数据表明，体重、运动动力和骨密度受到E-2的积极影响。类固醇雌激素在胫骨小梁区起保护骨骼的作用，增加运动动力，对抗体重的增加。在饲喂富含异黄酮的饲料的动物中没有观察到所有这些影响。
Reduced estrogen levels occurring during menopause in woman are accompanied by a variety of disorders, e.g., hot flushes, depressions, osteoporosis, increase of body weight, and reduced movement drive. In this study we investigated the combined effects of physical activity, estradiol substitution, and a phytoestrogen-rich diet on bone mineral density, increase of body weight, and movement drive in an animal model. Ovariectomized (OVX) female Wistar rats were either fed an isoflavone-rich diet (IRD) or substituted with 17 beta-estradiol (E-2) for 3 months. Sham-operated rats (Sham) and vehicle-treated OVX animals served as controls. One half of the animals had the opportunity of voluntary wheel running. OVX rats displayed an eight times lower movement activity than Sham animals. E-2 treatment, but not IRD, significantly increased the movement activity of OVX rats. During 3 months the lowest increase of body weight was observed in Sham animals, the highest rate in OVX animals. Along with running activity E-2 treatment, but not IRD, also lowered the increase of body weight significantly compared to OVX animals. Bone mineral density (BMD) in the trabecular area of the tibia was strongly reduced in OVX rats compared to Sham animals. In contrast to IRD, E-2 substitution resulted in a protection of BMD in this area compared to OVX animals. Our data demonstrate that body weight, movement drive, and BMD are positively influenced by E-2. The steroid estrogen acts in the trabecular area of the tibia in a bone-protective manner, increases movement drive and antagonizes the increase of body weight. All these effects could not be observed in animals fed an isoflavone-rich diet.