Survival of Vibrio vulnificus in whole blood from patients with chronic liver diseases:: Association with phagocytosis by neutrophils and serum ferritin levels
Survival of Vibrio vulnificus in whole blood from patients with chronic liver diseases:: Association with phagocytosis by neutrophils and serum ferritin levels
复制标题
DOI：
10.1086/314554
复制
发表时间：
1999-01-01
影响因子：
6.4
通讯作者：
Wang, ST
中科院分区：
文献类型：
--
作者：
Hor, LI;Chang, TT;Wang, ST
创伤弧菌引起严重的伤口感染和败血症，主要发生在慢性肝病患者中。从健康志愿者和患有慢性肝炎、肝硬化和肝癌的患者采集的全血中分析该微生物的存活作为敏感性的指标。孵育5小时后血液中的细菌数量随着肝病的严重程度而增加，并且在肝癌患者和健康志愿者之间存在显著差异全血中创伤弧菌存活率与血清铁蛋白浓度呈正相关（P <0.05）（r = .266; P < .05）和转铁蛋白铁饱和度百分比（r = .200; P < .05）并与血清C4浓度（u = -.198; P < .05）和中性粒细胞吞噬作用（r = -.204; P < .05）呈负相关。在这些参数中，低吞噬活性（P <0.01）和血液中的高铁蛋白水平（P <0.01）是独立的预测因子。
Vibrio vulnificus causes severe wound infections and sepsis, mostly in persons with chronic liver diseases. Survival of this organism in the whole blood collected from healthy volunteers and patients with chronic hepatitis, liver cirrhosis, and hepatoma was analyzed as an indication of susceptibility, The bacterial numbers in the blood after 5 h of incubation tended to increase with the severity of the liver disease and differed significantly between hepatoma patients and healthy volunteers (P < .05), Survival of V. vulnificus in the whole blood correlated positively with serum ferritin concentration (r = .266; P < .05) and percentage of transferrin iron saturation (r = .200; P < .05) and correlated negatively with serum C4 concentration (u = -.198; P < .05) and phagocytosis by neutrophils (r = -.204; P < .05). Among these parameters, low phagocytosis activity (P < .01) and high ferritin level (P < .01) in the blood were the independent predictors.