Effects of perinatal dioxin exposure on neonatal electroencephalography (EEG) activity of the quiet sleep stage in the most contaminated area from Agent Orange in Vietnam
Effects of perinatal dioxin exposure on neonatal electroencephalography (EEG) activity of the quiet sleep stage in the most contaminated area from Agent Orange in Vietnam
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DOI：
10.1016/j.ijheh.2020.113661
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发表时间：
2021-03-01
影响因子：
6
通讯作者：
Nishijo, Hisao
中科院分区：
文献类型：
--
作者：
Pham, Ngoc Thao;Nishijo, Muneko;Nishijo, Hisao
目的：探讨围产期二恶英暴露的影响表明二恶英在母乳中对新生儿脑电图（EEG）功率在安静的睡眠阶段，并与神经发育的结果在2岁的年龄。研究设计：五十一对母亲和新生儿在安静的睡眠阶段从出生队列招募在边和市，越南的一个县医院新生儿脑电图分析。根据安静睡眠阶段的脑电数据，计算了短脉冲间期和高电压脉冲的相对脑电功率。43对母子参加了为期2年的随访调查，以检查神经发育使用Bayley-III量表和注视行为表现出的固定时间在一个孩子的脸上说话的视频。结果：围产期二恶英暴露，尤其是2，3，7，8-四氯二苯并对二恶英（TCDD）暴露，对安静睡眠期脑电相对功率的影响主要集中在短阵内部分。在爆发间隔内，左半球额叶δ功率降低，额叶和顶叶α功率值增加，右半球颞叶β功率值增加与TCDD暴露增加相关，具有显著的剂量-反应关系。几乎没有在这些大脑区域的相对功率值与Bayley III分数，但相对三角洲功率值显着相关，在2岁左右的左额叶和顶叶区域的面部固定持续时间：围产期二恶英暴露影响神经元活动在安静的睡眠阶段，导致沟通能力差的凝视行为在幼儿期。
Objective: To investigate the effects of perinatal dioxin exposure indicated by dioxins in breast milk on neonatal electroencephalography (EEG) power in the quiet sleep stage, and associations with neurodevelopmental outcomes at 2 years of age.Study design: Fifty-one mother-newborn pairs were enrolled for neonatal EEG analysis in the quiet sleep stage from a birth cohort recruited at a prefecture hospital in Bien Hoa city, Vietnam. Relative EEG power in intraburst-intervals and high-voltage-bursts in the trace alternant pattern were computed from EEG data during the quiet sleep stage. Forty-three mother-child pairs participated in a 2-year follow-up survey to examine neurodevelopment using the Bayley-III scale and gaze behavior exhibited by fixation duration on the face of a child talking in videos. The general linear model and regression linear model were used for data analysis after adjusting for confounding factors.Results: Perinatal dioxin exposure, particularly 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure, influenced relative EEG power values mainly in the intra-burst-interval part of the trace alternant pattern in the quiet sleep stage. In intra-burst-intervals, decreased frontal delta power and increased frontal and parietal alpha power values in the left hemisphere and temporal beta power values in the right hemisphere were associated with increased TCDD exposure, with significant dose-response relationships. Almost none of the relative power values in these brain regions were associated with Bayley III scores, but relative delta power values were significantly associated with face fixation duration in left frontal and parietal regions at 2 years of age.Conclusion: Perinatal dioxin exposure influences neuronal activity in the quiet sleep stage, leading to poor communication ability indicated by gaze behavior in early childhood.