Development of visual motion integration involves coordination of multiple cortical stages.
Development of visual motion integration involves coordination of multiple cortical stages.
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DOI：
10.7554/elife.59798
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发表时间：
2021-03-22
期刊：
影响因子：
7.7
通讯作者：
Nielsen KJ
中科院分区：
文献类型：
--
作者：
Lempel AA;Nielsen KJ
皮质功能的一个中心特征是信息的分级处理。目前对皮层处理级联如何发展知之甚少。在这里，我们调查的联合发展的两个节点的雪貂的视觉运动通路，初级视皮层（V1），和更高级别的区域PSS。在成年动物中，运动处理在这些区域之间从局部计算过渡到全局计算。我们现在表明，PSS全球运动信号出现一个星期后，V1和PSS方向选择性的发展。至关重要的是，V1对更复杂的运动刺激的反应是平行变化的，其方式与支持增加的PSS运动整合一致。同时，这些V1响应取决于来自PSS的反馈。我们的研究结果表明，发展不仅仅是在不同的视觉区域平行进行，它是在网络节点之间协调进行的。这对于理解视觉体验和发育障碍如何影响发育中的视觉系统具有重要意义。
A central feature of cortical function is hierarchical processing of information. Little is currently known about how cortical processing cascades develop. Here, we investigate the joint development of two nodes of the ferret’s visual motion pathway, primary visual cortex (V1), and higher-level area PSS. In adult animals, motion processing transitions from local to global computations between these areas. We now show that PSS global motion signals emerge a week after the development of V1 and PSS direction selectivity. Crucially, V1 responses to more complex motion stimuli change in parallel, in a manner consistent with supporting increased PSS motion integration. At the same time, these V1 responses depend on feedback from PSS. Our findings suggest that development does not just proceed in parallel in different visual areas, it is coordinated across network nodes. This has important implications for understanding how visual experience and developmental disorders can influence the developing visual system.