Part 1: Dual-tuned proton/sodium magnetic resonance imaging of the lumbar spine in a rabbit model.
Part 1: Dual-tuned proton/sodium magnetic resonance imaging of the lumbar spine in a rabbit model.
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DOI：
10.1097/brs.0b013e318259ee98
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发表时间：
2012-08-15
期刊：
影响因子：
3
通讯作者：
Bae KT
中科院分区：
文献类型：
--
作者：
Moon CH;Kim JH;Jacobs L;Zhao T;Sowa G;Vo N;Kang J;Bae KT
用于兔脊柱磁共振成像的双调谐质子/钠射频线圈的研制及椎间盘内钠浓度的定量测定。目的：建立兔腰椎双调谐质子/钠磁共振成像，探讨蛋白多糖基质含量与椎间盘退变（IDD）的关系。IDD是一种常见的慢性疾病，可能导致背部疼痛、活动受限和残疾。早期IDD包括椎间盘中蛋白聚糖基质和水含量的损失。钠磁共振成像是一种很有前途的无创技术，用于定量测量与IDD相关的蛋白多糖变化。结合结构（质子）和生化（钠）磁共振成像有助于研究与椎间盘退变相关的形态学和分子变化。研制了兔脊柱多通道双调谐质子/钠收发射频线圈，并在3T人体扫描仪上进行了优化，其中钠线圈分配8个通道，质子线圈分配4个通道。利用涡轮自旋回波和双回波稳态序列获得高分辨率解剖质子图像。通过校正射频场不均匀性导致的信号衰减、钠磁共振弛豫时间和光盘厚度的钠磁共振图像来定量光盘的钠浓度。取12只家兔（~1岁，雌性，5.2±0.4 kg）测定椎间盘钠浓度。利用内部双调谐质子/钠射频线圈在3T下成功获得兔椎间盘（厚度≤2mm）的高分辨率体内质子和钠磁共振图像。每组图像的总采集时间约为40分钟。正常家兔腰椎间盘钠浓度测量值为269.7±6.3 mM，测量结果重复性高，变异系数为5.3%。使用我们新开发的双调谐多通道质子/钠射频线圈在3T下可靠地测量了兔腰椎间盘的钠浓度。
Development of a dual-tuned proton/sodium RF coil for magnetic resonance (MR) imaging of the rabbit spine and quantification of sodium concentration in intervertebral discs. To develop the dual-tuned proton/sodium MR imaging of rabbit lumbar spine to investigate proteoglycan matrix content and intervertebral disc degeneration (IDD). IDD is a common chronic condition that may lead to back pain, limited activity, and disability. Early stage IDD involves the loss of proteoglycan matrix and water content in the disc. Sodium MR imaging is a promising noninvasive technique for quantitative measurement of proteoglycan changes associated with IDD. The combined structural (proton) and biochemical (sodium) MR imaging facilitates the investigation of morphological and molecular changes associated with degeneration of discs. Multi-channel dual-tuned proton/sodium transceiver RF coil of the rabbit spine was developed and optimized at 3T human scanner – eight channels allocated for the sodium coil and four channels for the proton coil. High-resolution anatomy proton images of the discs were acquired using turbo spin echo and dual echo steady state sequence. Sodium concentration of the discs was quantified from sodium MR images that were calibrated for signal attenuation due to RF field inhomogeneity, sodium MR relaxation times, and disc thickness. Twelve rabbits (~1 year old, female, 5.2 ± 0.4 kg) were used for measuring disc sodium concentration. High-resolution in vivo proton and sodium MR images of rabbit discs (≤ 2-mm thickness) were successfully obtained using an in-house dual-tuned proton/sodium RF coil at 3T. The total acquisition time for each set of images was approximately 40 minutes. Sodium concentration of normal rabbit lumbar discs was measured 269.7 ± 6.3 mM, and this measurement was highly reproducible, with 5.3% of coefficient of variation. Sodium concentrations of rabbit lumbar discs were reliably measured using our newly developed dual-tuned multi-channel proton/sodium RF coil at 3T.