Temporal relationship between environmental influenza A and Epstein-Barr viral infections and high multiple sclerosis relapse occurrence
Temporal relationship between environmental influenza A and Epstein-Barr viral infections and high multiple sclerosis relapse occurrence
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DOI：
10.1177/1352458510394397
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发表时间：
2011-06-01
影响因子：
5.8
通讯作者：
Salmi, Aimo
中科院分区：
文献类型：
--
作者：
Oikonen, Mervi;Laaksonen, Mikko;Salmi, Aimo
背景资料：多发性硬化症（MS）复发与病毒和细菌感染流行的MS患者谁没有使用干扰素Objectives：我们研究了环境病毒感染在一般人群中是否可以与MS复发率增加使用回顾性数据从1986年至1995年，当干扰素还没有。使用逻辑回归模型回顾性比较了图尔库大学医院档案中407例MS患者的每月复发率和1986年至2008年芬兰西南部一般人群中10种不同的特异性诊断病毒感染流行病的数据。1995.结果是非常高复发率与低复发率或中度与低复发率的比值比（OR）。在普通人群中确诊的甲型流感病例达到高峰后，MS复发发生率是非常高的6.5倍（95% CI 1.8-24.0）和7.1倍的可能性是中度高（95% CI 1.5-33.2）。EB病毒（EBV）感染后MS复发计数也增加（OR 4.4，95%CI 1.3-15.1），但我们发现腺病毒感染与MS复发无显著相关性。MS复发发生率在夏季7月至8月最低（卡方检验，p < 0.01）。结论：我们的研究结果表明，在一般人群中，甲型流感病毒和EBV病毒感染与MS患者的加重发生率较高相关，因此环境感染数据应包括在MS复发的流行病学模型中。
Background: Multiple sclerosis (MS) relapses have been associated with viral and bacterial infection epidemics in MS patients who have not used interferon.Objectives: We studied whether environmental viral infections in the general population can be associated with increased MS relapse occurrence using retrospective data from 1986 to 1995 when interferons were not yet available.Methods: Logistic regression modelling was used to compare retrospectively the monthly relapse occurrence from 407 MS patients in Turku University hospital archives and data on ten different specifically diagnosed viral infection epidemics in the general population of Southwestern Finland from 1986 to 1995. The outcome was the odds ratio (OR) of very high relapse occurrence versus low relapse occurrence, or moderate versus low relapse occurrence.Results: After a peak in diagnosed influenza A cases in the general population, the MS relapse occurrence was 6.5 times more likely to be very high (95% CI 1.8-24.0) and 7.1 times more likely to be moderately high (95% CI 1.5-33.2). An increase in MS relapse counts also followed Epstein-Barr virus (EBV) infections (OR 4.4, 95% CI 1.3-15.1), but we found no significant association with adenovirus infections and MS relapses. The MS relapse occurrence was lowest in the summer months July-August (Chi-square test, p < 0.01).Conclusions: Our findings suggest that influenza A and EBV viral infections in the general population are associated with a higher occurrence of exacerbations in MS patients, and thus environmental infection data should be included in epidemiological models on MS relapses.