ELECTRIC AND MAGNETIC-FIELDS FROM TWO-DIMENSIONAL ANISOTROPIC BISYNCYTIA
ELECTRIC AND MAGNETIC-FIELDS FROM TWO-DIMENSIONAL ANISOTROPIC BISYNCYTIA
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DOI：
10.1016/s0006-3495(87)83381-7
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发表时间：
1987-04-01
影响因子：
3.4
通讯作者：
WIKSWO, JP
中科院分区：
文献类型：
--
作者：
SEPULVEDA, NG;WIKSWO, JP
在宏观上，心脏组织可以被认为是一种双参数、各向异性的导体，其中简单的去极化波前产生复杂的电流分布。由于这样的分布可能很难用电学技术测量，我们开发了一个数学模型来确定这些电流的磁定域化的可行性。将有限元方法应用于具有各向异性电导率的理想化二维双胞体，计算了圆形退极波前的胞内和胞外电势、电流分布和磁场。计算出的磁场距离组织1毫米，完全在SQUID磁强计的灵敏度范围内。我们的结果表明，复杂的双胞体电流模式可以用磁性来研究，这些研究应该为了解心脏组织的电各向异性提供有价值的见解。
Cardiac tissue can be considered macroscopically as a bidomain, anisotropic conductor in which simple depolarization wavefronts produce complex current distribution. Since such distributions may be difficult to measure using electrical techniques, we have developed a mathematical model to determine the feasibility of magnetic localization of these currents. By applying the finite element method to an idealized two-dimensional bisyncytium with anisotropic conductivities, we have calculated the intracellular and extracellular potentials, the current distributions, and the magnetic fields for a circular depolarization wavefront. The calculated magnetic field 1 mm from the tissue is well within the sensitivity of a SQUID magnetometer. Our results show that complex bisyncytial current patterns can be studied magnetically, and these studies should provide valuable insight regarding the electrical anisotropy of cardiac tissue.