RRas2, RhoG and T-cell phagocytosis.
RRas2, RhoG and T-cell phagocytosis.
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DOI：
10.4161/sgtp.19138
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Martínez-Martín N
中科院分区：
文献类型：
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作者：
Alarcón B;Martínez-Martín N
经典Ras亚家族成员（K-Ras、N-Ras和H-Ras）的激活突变和过表达已被广泛研究为人类癌症发展中的关键事件。尽管其成员之一（TC 21或RRas 2）在体外具有强烈的转化作用，但其最近的亲属Ras相关（RRas）亚家族成员在癌症中的作用研究较少。然而，尽管出版物很少，但几项研究表明野生型TC 21在不同类型的癌和淋巴瘤中过表达。如果说RRas成员在癌症中的研究还处于起步阶段，那么它们在生理功能中的作用就更落后了。例如，T和B细胞免疫学家仍然使用模糊的术语“Ras激活”，而没有指出Ras家族分子确实在干预。从这个角度来看，我们讨论的参与TC 21在特定的过程中的T细胞抗原受体内化的免疫突触和收购的膜片段从抗原呈递细胞的吞噬作用。
Activating mutations and overexpression of classical Ras subfamily members (K-Ras, N-Ras and H-Ras) have been widely investigated as key events in the development of human cancers. The role in cancer of its closest relatives, the Ras-related (RRas) subfamily members, has been less studied despite the fact that one of its members (TC21 or RRas2) is strongly transforming in vitro. Nevertheless, and in spite the paucity of publications, several studies have shown that wild type TC21 is overexpressed in different types of carcinomas and lymphomas. If the study of RRas members in cancer is still in its infancy, their role in physiological functions is even behind. For instance, T and B cell immunologists still use the vague term “Ras activation” without indication of what Ras family molecule is indeed intervening. In this view, we discuss the participation of TC21 in the specific process of T cell antigen receptor internalization from the immunological synapse and acquisition of membrane fragments from the antigen presenting cells by phagocytosis.