MAPPING OF THE HUMAN-GENE FOR EPIDERMAL GROWTH-FACTOR RECEPTOR (EGFR) ON THE P13-]Q22 REGION OF CHROMOSOME-7
MAPPING OF THE HUMAN-GENE FOR EPIDERMAL GROWTH-FACTOR RECEPTOR (EGFR) ON THE P13-]Q22 REGION OF CHROMOSOME-7
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DOI：
10.1159/000131829
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
SHIMIZU, N
中科院分区：
文献类型：
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作者：
KONDO, I;SHIMIZU, N
表皮生长因子受体（EGFR）的结构基因可定位于p22 →。人7号染色体qter区。通过将EGFR缺陷的小鼠A9细胞与人二倍体成纤维细胞系GM 1356，46，XX，t（1;7）（p34;p13）和GM 2068，46，XX，t（6;7）（q27;q22）融合产生两个系列的人-小鼠细胞杂交体，两者都具有EGF受体。EGF结合能力在前一系列细胞杂交体中的表达与含有7 p13 →的人易位染色体的保留相关。qter区域，并且在后一系列的细胞杂种中，它与含有7 pter →的人易位染色体的保留相关。q22区。EGFR基因可定位于p13 →。7号染色体q22区。
The structural gene for epidermal growth factor receptor (EGFR) can be mapped to the p22 .fwdarw. qter region of human chromosome 7. Two series of human-mouse cell hybrids were produced by fusing mouse A9 cells that are deficient in EGFR with the human diploid fibroblast lines GM1356, 46,XX,t(1;7)(p34;p13), and GM2068, 46,XX,t(6;7)(q27;q22), both of which possess EGF receptors. Expression of EGF binding ability in the former series of cell hybrids was correlated with the retention of the human translocation chromosome containing the 7p13 .fwdarw. qter region, and in the latter series of cell hybrid it was correlated with the retention of the human translocation chromosome containing the 7pter .fwdarw. q22 region. The EGFR gene can be localized in the p13 .fwdarw. q22 region of chromosome 7.