Particle size of tin and phytate colloid in sentinel node identification
Particle size of tin and phytate colloid in sentinel node identification
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DOI：
10.1016/j.jss.2004.02.011
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发表时间：
2004-09-01
影响因子：
2.2
通讯作者：
Aikou, T
中科院分区：
文献类型：
--
作者：
Higashi, H;Natsugoe, S;Aikou, T
背景前哨淋巴结导航手术（SNNS）最近已被引入各种类型的癌症。许多放射性同位素被用作SNNS的示踪剂。然而，很少有报道研究用于SNNS的同位素胶体的颗粒尺寸。锡和植酸盐胶体在本研究中使用。将等渗氯化钠和锡溶液以1：4、1：2、1：1、2：1和4：1的比例混合。将钙溶液和Tc-植酸盐以1：4、1：2、1：1、2：1和4：1的比例混合。使用Coulter Model N4SD亚微米颗粒分析仪测量粒度。当等渗氯化钠和锡溶液以1：4、1：2、1：1、2：1和4：1的比例混合时，粒径分别为47 9、96 10、712 +/- 83、925 +/- 66和1079 +/- 132 nm。随着锡液比例的降低，胶体粒径增大。植酸盐胶体的粒度根据钙浓度从174 +/- 39 nm变化到1222 +/- 283 nm。随着植酸盐溶液比例的降低，植酸盐胶体粒径变大。我们确定，锡和植酸盐胶体的粒径是可控的，通过操纵的条件下，胶体的形式。这些结果将提供有用的信息时，SNNS进行。(C)2004年爱思唯尔公司All rights reserved.
Background. Sentinel node navigation surgery (SNNS) has recently been introduced for various types of carcinoma. Numerous radioisotopes are used as tracers for SNNS. However, few reports have examined particle sizes of isotope colloids used in SNNS.Materials and methods. Tin and phytate colloids were used in the present study. Isotonic sodium chloride and tin solutions were mixed ratios of 1:4,1:2, 1:1, 2:1, and 4:1. Calcium solution and Tc-phytate were mixed at ratios of 1:4, 1:2, 1:1, 2:1 and 4:1. Particle size was measured using a Coulter Model N4SD Sub-micron Particle Analyzer.Results. When isotonic sodium chloride and tin solutions were mixed at ratios of 1:4, 1:2, 1:1, 2:1, and 4:1, particle size was 47 9, 96 10, 712 +/- 83, 925 +/- 66 and 1079 +/- 132 nm, respectively. As the ratio of tin solution decreased, colloid particle size increased. Particle size of phytate colloid varied from 174 +/- 39 nm to 1222 +/- 283 nm, according to calcium concentration. Phytate colloid particle size became larger as the ratio of phytate solution decreased.Conclusions. We ascertained that the particle size of tin and phytate colloids is controllable by manipulating the conditions under which the colloids form. These results will offer useful information when SNNS is performed. (C) 2004 Elsevier Inc. All rights reserved.