Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate.
Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate.
复制标题
COVID-19中的心血管功能障碍：内皮细胞损伤与乳酸之间的关系。
DOI：
10.3389/fimmu.2022.868679
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发表时间：
2022
影响因子：
7.3
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Yang K;Holt M;Fan M;Lam V;Yang Y;Ha T;Williams DL;Li C;Wang X
2019年冠状病毒病（COVID-19）是一种由一种名为严重急性呼吸道综合征冠状病毒-2（SARS-CoV-2）的新病毒传播的传染性呼吸道疾病，已导致全球医疗危机。来自COVID-19患者的新证据表明，内皮细胞损伤在COVID-19发病机制中起着核心作用，可能是COVID-19严重程度和死亡率的主要因素。与其他传染病一样，COVID-19的发病机制与代谢过程密切相关。乳酸是COVID-19的潜在生物标志物，最近已被证明可介导内皮屏障功能障碍。本文就SARS-CoV-2感染引起的心血管损伤和代谢改变作一综述。我们还提出，乳酸在COVID-19驱动的内皮细胞损伤中起着潜在的作用。
Coronavirus disease 2019 (COVID-19), an infectious respiratory disease propagated by a new virus known as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has resulted in global healthcare crises. Emerging evidence from patients with COVID-19 suggests that endothelial cell damage plays a central role in COVID-19 pathogenesis and could be a major contributor to the severity and mortality of COVID-19. Like other infectious diseases, the pathogenesis of COVID-19 is closely associated with metabolic processes. Lactate, a potential biomarker in COVID-19, has recently been shown to mediate endothelial barrier dysfunction. In this review, we provide an overview of cardiovascular injuries and metabolic alterations caused by SARS-CoV-2 infection. We also propose that lactate plays a potential role in COVID-19-driven endothelial cell injury.