INTERRELATIONSHIPS BETWEEN DENSITOMETRIC, GEOMETRIC, AND MECHANICAL-PROPERTIES OF RAT FEMORA - INFERENCES CONCERNING MECHANICAL REGULATION OF BONE MODELING
INTERRELATIONSHIPS BETWEEN DENSITOMETRIC, GEOMETRIC, AND MECHANICAL-PROPERTIES OF RAT FEMORA - INFERENCES CONCERNING MECHANICAL REGULATION OF BONE MODELING
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DOI：
10.1002/jbmr.5650081113
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发表时间：
1993-11-01
影响因子：
6.2
通讯作者：
ZANCHETTA, JR
中科院分区：
文献类型：
--
作者：
FERRETTI, JL;CAPOZZA, RF;ZANCHETTA, JR
两种不同品系的大鼠股骨中的骨几何特性对骨材料质量的差异有补偿作用。在此基础上，根据Frost的恒力理论，提出了一种控制集成骨力学性能的反馈机制。在45只不同性别、年龄和大小的正常Wistar大鼠的股骨骨干中，骨材料的横截面结构(惯性矩)和矿物质依赖的硬度(弹性模量)之间存在负相关，这为这一系统提供了证据。研究发现，完整骨干的强度和硬度取决于横截面惯性和体重，而不是骨密度。这些发现被解释为支持这样一种假设，即在骨骼硬度施加的约束下，由于生长过程中骨骼建模的空间方向导致的骨干横断面设计的建筑效率作为体重依赖的骨应变历史的函数而优化。结果表明，生物量的调节作用与系统设定点的确定有关，并解释了在几何不均匀群体的研究中通常观察到的矿物质密度与长骨的强度或硬度之间缺乏直接相关性。
A compensation for differences in bone material qualtiy by bone geometric properties in femora from two different strains of rats was previously shown by us. A feedback mechanism controlling the mechanical properties of the integrated bones was then proposed, in accordance with Frost's mechanostat theory. Evidence of such a system is now offered by the finding of a negative correlation between the modeling-dependent cross-sectional architecture (moment of inertia) and the mineral-dependent stiffness (elastic modulus) of bone material in the femoral diaphyses of 45 normal Wistar rats of different sexes, ages, and sizes. The strength and stiffness of the integrated diaphyses were found to depend on both cross-sectional inertia and body weight, not on bone mineral density. These findings are interpreted as supporting the hypothesis that the architectural efficiency of diaphyseal cross-sectional design resulting from the spatial orientation of bone modeling during growth is optimized as a function of the body weight-dependent bone strain history, within the constraints imposed by bone stiffness. Results suggest a modulating role of biomass, related to the system set point determination, and explain the usually observed lack of a direct correlation between mineral density and strength or stiffness of long bones in studies of geometrically inhomogeneous populations.