Reduction of surgery induced peritoneal adhesions by methylene blue
Reduction of surgery induced peritoneal adhesions by methylene blue
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DOI：
10.1016/s0002-9610(97)00232-8
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发表时间：
1998-01-01
影响因子：
3
通讯作者：
Kluger, Y
中科院分区：
文献类型：
--
作者：
Galili, Y;Ben-Abraham, R;Kluger, Y
背景技术背景：可能参与的炎症介质，如一氧化氮（NO），和抗氧化剂的保护作用的报告，导致我们测试的有效性，亚甲蓝和NO合成抑制剂在减少adhesion formation.METHODS：代大鼠粘连，刮前子宫角壁，其次是腹膜内注射生理盐水，亚甲蓝，或N α-t-BOC-ω-硝基-L-精氨酸。结果：盐水组和NO合成酶抑制剂组的粘连发生率分别为95%和5%，亚甲基蓝组的粘连发生率分别为5%和5%。美蓝组粘连严重程度较低（P
BACKGROUND: The possible involvement of inflammatory mediators such as nitric oxide (NO), and reports of protective effects of antioxidants, led us to test the effectiveness of methylene blue and NO synthesis inhibitor in reducing adhesion formation.METHODS: Generation of adhesions in rats, by scraping the anterior uterine horn wall, was followed by intraperitoneal administration of saline, methylene blue, or N alpha-t-BOC-omega-nitro-L-arginine. Additional rats received identical treatments, but without the serosal damage, Two weeks later, formation of adhesions was quantitatively graded.RESULTS: Adhesions were found in 95% of the rats treated with saline or NO synthetase inhibitor had severe adhesions, in contrast to 5% of the methylene blue treated rats. Severity of adhesion was lower in the methylene blue group (P