SYNTHESIS AND HYBRIDIZATION PROPERTIES OF AMIDE-LINKED THYMIDINE DIMERS INCORPORATED INTO OLIGODEOXYNUCLEOTIDES
SYNTHESIS AND HYBRIDIZATION PROPERTIES OF AMIDE-LINKED THYMIDINE DIMERS INCORPORATED INTO OLIGODEOXYNUCLEOTIDES
复制标题
DOI：
10.1016/s0040-4039(00)73923-2
复制
发表时间：
1993-08-20
影响因子：
1.8
通讯作者：
GIANNARIS, PA
中科院分区：
文献类型：
--
作者：
IDZIAK, I;JUST, G;GIANNARIS, PA
已经制备了通过酰胺或N-甲基酰胺键连接的胸苷二聚体。通过固相合成，二聚体各自被掺入正常DNA链三次。热变性研究表明，这些修改引起很少或没有不稳定的DNA：RNA双链体。
Thymidine dimers, connected by amide or N-methyl amide linkages, have been prepared. The dimers have each been incorporated three times into normal strands of DNA by solid phase synthesis. Thermal denaturation studies indicated that these modifications caused little or no destabilization of the DNA:RNA duplex.