Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma
Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma
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DOI：
10.1016/j.ejso.2006.10.036
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发表时间：
2007-03-01
期刊：
影响因子：
3.8
通讯作者：
Lee, S. -D.
中科院分区：
文献类型：
--
作者：
Hsia, C. -Y.;Huo, T-I.;Lee, S. -D.
目的：血清甲胎蛋白（AFP）是肝细胞癌（HCC）最重要的肿瘤标志物。以前的研究表明，肝细胞癌还与白细胞介素（IL）-6，IL-10和肝细胞生长因子（HGF）水平升高有关。本研究探讨了这些细胞因子作为肿瘤标志物的作用HCC.Method：共有128名成年人前瞻性地入选，并分为四组：正常人（n = 29），慢性B或丙型肝炎（n = 50），非HCC肿瘤（n = 23）和HCC（n = 26）。结果：正常人血清中IL-6、IL-10（>= 3 pg/ml）、HGF（> 1000 pg/ml）、AFP（> 20 ng/ml）的阳性率仅为0-3%。与慢性肝炎或非HCC肿瘤患者相比，HCC患者的IL-6和IL-10水平更高（p < 0.05），而HGF水平在HCC患者中没有显著升高。在AFP水平低于20 ng/ml的患者中，IL-6、IL-10的表达与HCC的发生有显著相关性（p < 0.05）。大肝癌（> 5cm）患者更常具有升高的IL-6、IL-10或AFP水平（p值均< 0.05）。结论：血清IL-6和IL-10水平在肝癌患者中频繁升高，但在良性肝病或非肝癌肿瘤中不升高。IL-6和IL-10可能有助于识别低AFP水平的HCC患者的子集，并且可以作为这些患者的互补肿瘤标志物。(c)2006爱思唯尔有限公司保留所有权利。
Aim: Serum alpha-fetoprotein (AFP) is the most important tumor marker for hepatocellular carcinoma (HCC). Previous reports indicated that HCC was also associated with increased levels of interleukin (IL)-6, IL-10 and hepatocyte growth factor (HGF). This study investigated the role of these cytokines as tumor markers for HCC.Method: A total of 128 adults were prospectively enrolled and categorized into four groups: normal subjects (n = 29), chronic hepatitis B or C (n = 50), non-HCC tumors (n = 23) and HCC (n = 26). Serum AFP, IL-6, IL-10 and HGF levels were determined in all subjects.Results: The expression of IL-6 or IL-10 (>= 3 pg/ml), or high level of HGF (> 1000 pg/ml) or AFP (> 20 ng/ml) was observed in only 0-3% of normal subjects. Patients with HCC more frequently had higher IL-6 and IL-10 levels (p < 0.05), whereas HGF levels in HCC patients were not significantly elevated compared to patients with chronic hepatitis or non-HCC tumors. Among patients with low (< 20 ng/ml) AFP level, IL-6 or IL-10 expression was significantly associated with the existence of HCC (p < 0.05). Patients with large (> 5 cm) HCC more often had increased IL-6, IL-10 or AFP levels (p values all < 0.05).Conclusions: Serum levels of IL-6 and IL-10 are frequently elevated in patients with HCC but not in benign liver disease or non-HCC tumors. IL-6 and IL-10 may help identify a subset of HCC patients with low AFP level, and may serve as complementary tumor markers in these patients. (c) 2006 Elsevier Ltd. All rights reserved.