Pilot study of cranial stimulation for symptom management in breast cancer.
Pilot study of cranial stimulation for symptom management in breast cancer.
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DOI：
10.1188/10.onf.476-483
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发表时间：
2010-07
影响因子：
1.9
通讯作者：
Taylor AG
中科院分区：
文献类型：
--
作者：
Lyon DE;Schubert C;Taylor AG
To examine the feasibility, relationships among variables, and preliminary outcomes of a self-directed complementary modality, cranial electrical stimulation (CES), for symptom management in women receiving chemotherapy for breast cancer. Biobehavioral pilot feasibility study. Two university-based cancer centers. 36 women with stage I-IIIA breast cancer scheduled to receive chemotherapy. Data were collected via interview, questionnaires, and interactive voice technology (IVR). Biomarkers were measured from a blood sample taken prior to the initial chemotherapy. Symptoms of depression, anxiety, fatigue, pain, and sleep disturbances; biomarkers (proinflammatory cytokines interleukin-6, tumor necrosis factor alpha [TNF-α0], interleukin-1 beta) and C-reactive protein [CRP]); and CES. CES appears to be a safe and acceptable modality during chemotherapy. Recruitment and retention were adequate. IVR was associated with missing data. Symptoms of depression, anxiety, fatigue, and sleep disturbances were highly correlated with each other, and most symptoms were correlated with CRP at baseline. Depression and TNF-α had a positive, significant relationship. Levels of depression increased over time and trended toward less increase in the CES group; however, the differences among groups were not statistically significant. The data support the feasibility of CES. Further testing in larger samples is needed to examine the efficacy of CES for symptom management of multiple, concurrent symptoms and to further develop the biobehavioral framework. Interventions that are effective at minimizing more than one target symptom are especially needed to provide optimal symptom management for women with breast cancer.
