SERUM 17BETA-ESTRADIOL AND ESTRONE LEVELS IN POSTMENOPAUSAL WOMEN WITH AND WITHOUT ENDOMETRIAL CANCER
SERUM 17BETA-ESTRADIOL AND ESTRONE LEVELS IN POSTMENOPAUSAL WOMEN WITH AND WITHOUT ENDOMETRIAL CANCER
复制标题
DOI：
10.1210/jcem-43-2-272
复制
发表时间：
1976-01-01
影响因子：
5.8
通讯作者：
YEN, SSC
中科院分区：
文献类型：
--
作者：
JUDD, HL;LUCAS, WE;YEN, SSC
血清17. beta。测定16例绝经后子宫内膜癌患者和10例子宫内膜正常的绝经后妇女（仅卵巢切除术前）在卵巢切除术前和术后6-8周的雌二醇（E2）和雌酮（E1）水平。E2组的平均基线无显著性差异(.+-。SE)水平在肿瘤(13.5 +-。1.1 pg/ml)和非肿瘤患者(11.7 .+-。1.4 pg / ml)。对于同一患者，平均基线E1水平为33.8 +-。2.4 pg/ml和28.5 +-。4.7 pg/ml也无显著性差异。肿瘤患者的平均体重(141.1 .+-。7.3 lb)与非肿瘤患者的平均体重（137.5 .+-）相似。6.3磅)。这一点很重要，因为E2和E1水平与这些绝经后妇女的体重和多余脂肪显著相关。循环雌激素水平与患者的身高、年龄或绝经年数无显著相关性。在子宫内膜癌患者中，平均E2（14.1 +-）。1.7 pg/ml)和E1(39.5 +-。7.3 pg/ml)水平与术前无显著差异。这些数据与绝经后妇女的观点一致，即大多数（如果不是全部的话）循环雌激素是由外周雄激素转化产生的，而这种转化受到肥胖的影响。绝经后子宫内膜癌患者的循环雌激素水平与年龄和体重相近但未患肿瘤的妇女相比无显著差异。
Serum 17.beta.-estradiol (E2) and estrone (E1) levels were measured before and 6-8 wk after ovariectomy in 16 postmenopausal women with endometrial cancer, and in 10 postmenopausal women with normal endometrium (preovariectomy only). For E2 no significant difference in the mean baseline (.+-. SE) level was found between the tumor (13.5 .+-. 1.1 pg/ml) and nontumor patients (11.7 .+-. 1.4 pg/ml). For the same patients the mean baseline E1 levels of 33.8 .+-. 2.4 pg/ml and 28.5 .+-. 4.7 pg/ml were also not significantly different. The mean body weight of the tumor patients (141.1 .+-. 7.3 lb) was similar to the mean weight of the nontumor subjects (137.5 .+-. 6.3 lb). This was of importance since E2 and E1 levels correlated significantly with body weight and excess fat in these postmenopausal women. The circulating estrogen levels did not correlate significantly with the patients'' height, age or years of menopause. In the patients with endometrial cancer the mean E2 (14.1 .+-. 1.7 pg/ml) and E1 (39.5 .+-. 7.3 pg/ml) levels after ovariectomy were not significantly different from the preoperative concentrations. These data are consistent with the concept that in postmenopausal women most, if not all, circulating estrogen is produced by peripheral conversion of androgens and that this conversion is influenced by obesity. Circulating estrogen levels are not significantly different in postmenopausal patients with endometrial cancer compared with women of a similar age and weight who do not have the tumor.