Frontal lobe hypometabolism and depression in Alzheimer's disease
Frontal lobe hypometabolism and depression in Alzheimer's disease
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DOI：
10.1212/wnl.50.2.380
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发表时间：
1998-02-01
期刊：
影响因子：
9.9
通讯作者：
Sasaki, M
中科院分区：
文献类型：
--
作者：
Hirono, N;Mori, E;Sasaki, M
抑郁症在阿尔茨海默病(AD)中很常见。对局灶性脑损伤的临床解剖学研究和对原发性抑郁症和继发于神经系统疾病的抑郁症的功能成像研究均显示额叶受累。额叶受累在阿尔茨海默病的抑郁中尚未建立。我们研究了局灶性脑代谢异常与AD抑郁的相关性。在53例可能患有轻中度残疾的AD患者中，我们使用神经精神病学问卷评估了抑郁的严重程度，并将抑郁评分与F-18-氟代脱氧葡萄糖和正电子发射计算机断层扫描(PET)确定的局部脑葡萄糖代谢相关联。有19名患者(36%)存在抑郁。抑郁评分与双侧额叶上部和左侧扣带回前部皮质的正常葡萄糖代谢率显著相关。这些结果表明，抑郁症与AD患者额叶活动减少之间存在关联，并支持抑郁症患者额叶受累，尤其是左侧受累，而与疾病病因无关。
Depression is common in Alzheimer's disease (AD). Clinicoanatomic studies in focal brain injuries and functional imaging studies both in primary depression and in depression secondary to neurologic diseases have demonstrated involvement of the frontal lobe. Frontal involvement has not been established in the depression of AD. We studied the correlation between focal brain metabolic abnormalities and depression in AD. In 53 patients with probable AD of minimal to moderate disability, we assessed the severity of depression using the Neuropsychiatric Inventory and correlated the depression score with regional cerebral glucose metabolism determined by F-18-fluorodeoxyglucose and PET. Depression was present in 19 patients (36%). The depression score correlated significantly with normalized glucose metabolic rates in the bilateral superior frontal and left anterior cingulate cortices. These results indicated an association between depression and decreased activity in the frontal lobe in AD and support frontal involvement, especially in the left side, in depression, irrespective of disease etiology.