RELATIONSHIP BETWEEN POSTHEPARIN PLASMA LIPASES AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL IN DIFFERENT TYPES OF DIABETES
RELATIONSHIP BETWEEN POSTHEPARIN PLASMA LIPASES AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL IN DIFFERENT TYPES OF DIABETES
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DOI：
10.1007/bf00296992
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发表时间：
1987-09-01
期刊：
影响因子：
8.2
通讯作者：
PYORALA, K
中科院分区：
文献类型：
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作者：
LAAKSO, M;SARLUND, H;PYORALA, K
我们检测了12例女性1型（胰岛素依赖型）糖尿病患者（胰高血糖素后C肽检测不到）、11例接受胰岛素治疗的女性2型（非胰岛素依赖型）糖尿病患者（胰高血糖素后C肽>0.60 nmol/l）和16例非糖尿病女性对照者的血脂、脂蛋白和肝素后血浆脂肪酶、脂蛋白脂肪酶和肝脂肪酶。这三组受试者在年龄和肥胖方面相似。1型糖尿病患者的胰岛素剂量与2型糖尿病患者相似。2型糖尿病患者的HDL和HDL 2胆固醇低于非糖尿病对照组（p<0.05），但1型糖尿病患者与非糖尿病对照组之间无差异。两组间脂蛋白脂酶活性无差异。2型糖尿病患者的脂蛋白脂酶和肝脂酶活性水平最高。在1型糖尿病患者（p<0.01）和2型糖尿病患者（p<0.001）中，脂蛋白脂酶活性与HDL胆固醇显著相关，但在对照组中不相关。在任何一组中，肝脂酶活性与HDL胆固醇均无显著相关性。总之，肝素后血浆脂蛋白脂酶和肝脂酶活性似乎不能解释1型和2型糖尿病患者之间HDL胆固醇浓度的差异。
We measured serum lipids, lipoproteins and postheparin plasma lipases, lipoprotein lipase and hepatic lipase, in 12 female patients with Type 1 (insulin-dependent) diabetes (postglucagon C-peptide undetectable), in 11 female insulin-treated patients with Type 2 (non-insulin-dependent) diabetes (postglucagon C-peptide >0.60 nmol/l) and in 16 non-diabetic female control subjects. These three groups of subjects were similar with respect to age and obesity. Insulin dose was similar in patients with Type 1 and with Type 2 diabetes. HDL and HDL2cholesterol were lower in patients with Type 2 diabetes than in non-diabetic control subjects (p<0.05) but did not differ between patients with Type 1 diabetes and non-diabetic control subjects. No difference in lipoprotein lipase activity was seen between the groups. The highest levels of lipoprotein lipase and hepatic lipase activities were observed in patients with Type 2 diabetes. Lipoprotein lipase activity correlated significantly with HDL cholesterol in patients with Type 1 diabetes (p<0.01) and in patients with Type 2 diabetes (p<0.001) but not in control subjects. Hepatic lipase activity did not correlate significantly with HDL cholesterol in any of the groups. In conclusion, postheparin plasma lipoprotein lipase and hepatic lipase activities do not seem to explain the difference in HDL cholesterol concentration between patients with Type 1 and Type 2 diabetes.