Serological response and persistence in schoolchildren with high baseline seropositive rate after receiving 2009 pandemic influenza A(H1N1) vaccine
Serological response and persistence in schoolchildren with high baseline seropositive rate after receiving 2009 pandemic influenza A(H1N1) vaccine
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DOI：
10.1016/j.vaccine.2010.11.016
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发表时间：
2011-01-17
期刊：
影响因子：
5.5
通讯作者：
Liao, Yu-Hsin
中科院分区：
文献类型：
--
作者：
Chao, Day-Yu;Cheng, Kuang-Fu;Liao, Yu-Hsin
通过一项以社区为基础的家庭研究，评估了目前2009年H1N1大流行性流感单价疫苗在基线血清阳性率较高的儿童中的血清学应答。在接种大流行疫苗后一个月，观察到儿童的血清保护率>90%，血清转换率>50%。在基线抗体滴度较低的儿童中，与仅接受大流行疫苗的儿童（86%）相比，在大流行疫苗接种前接受季节性三价灭活疫苗（TIV）的儿童的血清转换率（55%）显著较低。在接种疫苗后6个月，在>80%的呈现血清保护性抗体水平的儿童中观察到抗大流行性流感病毒的抗体持续存在。(C)2010爱思唯尔有限公司版权所有。
The serological response of the current 2009 H1N1 pandemic influenza monovalent vaccine in children exhibiting high baseline seropositive rate was evaluated though a community-based household study. Seroprotection rate of >90% and seroconversion rate of >50% were observed in children one month after receiving the pandemic vaccine. Among children with low baseline antibody titer, a significant lower seroconversion rate (55%) was observed in children who received seasonal trivalent inactivated vaccine (TIV) prior to pandemic vaccine, when compared with those receiving the pandemic vaccine only (86%). Persistence of antibody against the pandemic influenza virus was observed 6 months after vaccination in >80% of children presenting seroprotective antibody levels. (C) 2010 Elsevier Ltd. All rights reserved.