[Gustatory sensitivity threshold to table salt and efficacy of the treatment of newly diagnosed patients with antihypertensive therapy].
[Gustatory sensitivity threshold to table salt and efficacy of the treatment of newly diagnosed patients with antihypertensive therapy].
复制标题
初诊降压患者食盐味觉阈值及治疗效果[J].
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
E. S. Mazur
中科院分区：
文献类型：
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作者：
T. Petrova;N. D. Bazhenov;V. Mazur;E. S. Mazur
本文测定了128例高血压患者（男性79例，平均年龄54.1 ± 0.5岁）在降压治疗前和治疗后3个月对食盐的味觉敏感阈值（GST）和细胞外液量（EFV）。那些初始GST高的患者（0.32%溶液中的感测盐）的AP为161+-2/97+-1 mm Hg，心肌质量为235.1+-13.2 g，左心室舒张期大小为4.91+-0.07，而GST低的患者分别为151 +-1/93 +-1，203.5 +-7.8和4.71+-0.05。所有患者的AP和EFV分别下降14-19和12%。在GST高的患者中，摄入吲达帕胺后降低了49%，而未接受治疗的患者降低了24%。在最初低GST的患者中，仅在摄入利尿剂后降低（37%）。可以得出结论，GST的变化反映了激活的机制，导致AP的稳定下降。
Gustatory sensitivity threshold to table salt (GST) and extracellular fluid volume (EFV) were determined in 128 patients with arterial hypertension (mean age 54.1+-0.5 yr; 79 men) before and 3 month after antihypertensive therapy. Those with the initially high GST (sensing salt in its 0.32% solution) had AP 161+-2/97+-1 mm Hg, myocardial mass 235.1+-13.2 g and left ventricular diastolic size 4.91+-0.07 compared with 151 +- 1/93+-1, 203.5+-7.8 and 4.71+-0.05 respectively in patients with low GST. The treatment resulted in a decrease of AP and EFV by 14-19 and 12% respectively in all the patients. In those with high GST it decreased after intake of indapamide by 49% vs 24 % in the absence of therapy. In patients with initially low GST it decreased (by 37%) only after intake of diuretics. It is concluded that changes of GST reflect activation of mechanisms leading to a stable drop of AP.