Woehler and Liebig revisited: A small molecule reveals its secrets - The crystal structure of the unstable polymorph of benzamide solved after 173 years
Woehler and Liebig revisited: A small molecule reveals its secrets - The crystal structure of the unstable polymorph of benzamide solved after 173 years
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DOI：
10.1021/cg050187b
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发表时间：
2005-11-01
影响因子：
3.8
通讯作者：
Shankland, K
中科院分区：
文献类型：
--
作者：
Blagden, N;Davey, R;Shankland, K
在这项工作中，我们重新讨论了苯甲酰胺亚稳态晶型的问题。这是由利比格和沃勒在1832年首次发现的，但它的结构从未确定过。它展示了如何结合显微、光谱和衍射技术来最终解决这种高度亚稳的第二种形式的苯甲酰胺的结构。在高度不稳定的条件下，形态、无序和成核的组合导致了对这种不稳定多晶型的起源的一些猜测。
In this work, we revisit the question of the metastable crystal form of benzamide. This was first identified in 1832 by Liebig and Woehler, but its structure has never been determined. It is shown how a combination of microscopic, spectroscopic, and diffraction techniques have been used to solve, finally, the structure of this highly metastable Form II of benzamide. The combination of morphology, disorder, and nucleation under highly labile conditions lead to some speculation as to the origins of such an unstable polymorph.