An Exploratory Study: Prolonged Periods of Binocular Stimulation Can Provide an Effective Treatment for Childhood Amblyopia
An Exploratory Study: Prolonged Periods of Binocular Stimulation Can Provide an Effective Treatment for Childhood Amblyopia
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DOI：
10.1167/iovs.11-8219
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发表时间：
2012-02-01
影响因子：
4.4
通讯作者：
Cleary, Marie
中科院分区：
文献类型：
--
作者：
Knox, Pamela J.;Simmers, Anita J.;Cleary, Marie
目的.本研究的目的是探讨治疗儿童弱视的潜力与双眼刺激设计相关的视觉输入从两个眼睛。8名斜视、2名屈光参差、4名斜视和屈光参差性弱视患者（平均年龄8.5 ± 2.6岁）在一周的时间内进行了5次分视知觉学习任务（每次持续1小时）。训练范例包括一个简单的电脑游戏，要求受试者使用双眼来执行任务。弱视眼（AE）的平均视力（VA）有统计学显著改善（t（（13））= 5.46; P = 0.0001），从训练前的0.51 +/- 0.27 logMAR改善至训练后的0.42 +/- 0.28 logMAR，其中6名受试者获得0.1 logMAR或更多改善。3名受试者首次建立了可测量的立体视功能，训练后立体视锐度总体平均显著改善（t（（13））= 2.64; P = 0.02）。本研究中采用的基于分视的知觉学习疗法改善了AE的单眼VA和立体功能，验证了双眼方法治疗儿童弱视的可行性。（Invest Ophthalmol维斯科学。2012; 53：817-824）DOI：10.1167/iovs.11-8219
PURPOSE. The purpose of the present study was to explore the potential for treating childhood amblyopia with a binocular stimulus designed to correlate the visual input from both eyes.METHODS. Eight strabismic, two anisometropic, and four strabismic and anisometropic amblyopes (mean age, 8.5 +/- 2.6 years) undertook a dichoptic perceptual learning task for five sessions (each lasting 1 hour) over the course of a week. The training paradigm involved a simple computer game, which required the subject to use both eyes to perform the task.RESULTS. A statistically significant improvement (t((13)) = 5.46; P = 0.0001) in the mean visual acuity (VA) of the amblyopic eye (AE) was demonstrated, from 0.51 +/- 0.27 logMAR before training to 0.42 +/- 0.28 logMAR after training with six subjects gaining 0.1 logMAR or more of improvement. Measurable stereofunction was established for the first time in three subjects with an overall significant mean improvement in stereoacuity after training (t((13)) = 2.64; P = 0.02).CONCLUSIONS. The dichoptic-based perceptual learning therapy employed in the present study improved both the monocular VA of the AE and stereofunction, verifying the feasibility of a binocular approach in the treatment of childhood amblyopia. (Invest Ophthalmol Vis Sci. 2012; 53: 817-824) DOI: 10.1167/iovs.11-8219