In vitro characterization and mechanical properties of β-calcium silicate/POC composite as a bone fixation device.
In vitro characterization and mechanical properties of β-calcium silicate/POC composite as a bone fixation device.
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DOI：
10.1002/jbm.a.35074
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发表时间：
2014-11
期刊：
影响因子：
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通讯作者：
F. Shirazi;Ehsan Moghaddam;M. Mehrali;A. Oshkour;H. Metselaar;N. A. Kadri;Keivan Zandi;N. Abu
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文献类型：
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作者：
F. Shirazi;Ehsan Moghaddam;M. Mehrali;A. Oshkour;H. Metselaar;N. A. Kadri;Keivan Zandi;N. Abu
硅酸钙(CS，CaSiO_3)是一种生物活性、可降解性和生物相容性的陶瓷材料，在骨科手术领域具有潜在的应用前景。本研究的目的是制备和表征β-CS/聚柠檬酸辛二醇酯(POC)生物复合材料，以控制其失重，改善其生物力学性能。POC是生物相容性最好的聚合物之一，在生物医学工程中有着广泛的应用。通过将复合材料分别浸泡在磷酸盐缓冲盐水和模拟体液中，测定复合材料的降解性和生物活性。将人成骨细胞培养在复合材料上，检测其细胞增殖和黏附能力。结果表明，POC用量为40%时，复合材料的抗弯强度和抗压强度均有显著提高。随着β-CS含量的增加，细胞的降解性、生物活性和细胞增殖能力明显增强。
Calcium silicate (CS, CaSiO3 ) is a bioactive, degradable, and biocompatible ceramic and has been considered for its potential in the field of orthopedic surgery. The objective of this study is the fabrication and characterization of the β-CS/poly(1.8-octanediol citrate) (POC) biocomposite, with the goals of controlling its weight loss and improving its biological and mechanical properties. POC is one of the most biocompatible polymers, and it is widely used in biomedical engineering applications. The degradation and bioactivity of the composites were determined by soaking the composites in phosphate-buffered saline and simulated body fluid, respectively. Human osteoblast cells were cultured on the composites to determine their cell proliferation and adhesion. The results illustrated that the flexural and compressive strengths were significantly enhanced by a modification of 40% POC. It was also concluded that the degradation bioactivity and amelioration of cell proliferation increased significantly with an increasing β-CS content.