Transitions in infant learning are modulated by dopamine in the amygdala
Transitions in infant learning are modulated by dopamine in the amygdala
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DOI：
10.1038/nn.2403
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发表时间：
2009-11-01
影响因子：
25
通讯作者：
Sullivan, Regina M.
中科院分区：
文献类型：
--
作者：
Barr, Gordon A.;Moriceau, Stephanie;Sullivan, Regina M.
行为转变是发展的特征。自相矛盾的是，幼鼠更喜欢与电击相伴的气味，而年长的幼鼠则学会厌恶气味。这种转变依赖于杏仁核和皮质酮。通过微阵列和微透析，我们发现在偏好学习的杏仁核中多巴胺能突触前功能下调。注射皮质酮的8 d龄幼鼠和未注射皮质酮的12 d龄幼鼠学会了厌恶，杏仁核中的多巴胺能上调。注入杏仁核的多巴胺改变了对厌恶的偏好，而多巴胺拮抗剂则恢复了偏好学习。
Behavioral transitions characterize development. Young infant rats paradoxically prefer odors that are paired with shock, but older pups learn aversions. This transition is amygdala and corticosterone dependent. Using microarrays and microdialysis, we found downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone-injected 8-d-old pups and untreated 12-d-old pups learned aversions and had dopaminergic upregulation in the amygdala. Dopamine injection into the amygdala changed preferences to aversions, whereas dopamine antagonism reinstated preference learning.