Innovative Study Designs and Methods for Optimizing and Implementing Behavioral Interventions to Improve Health
Innovative Study Designs and Methods for Optimizing and Implementing Behavioral Interventions to Improve Health
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DOI：
10.1037/hea0000657
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发表时间：
2018-12-01
影响因子：
4.2
通讯作者：
Spring, Bonnie
中科院分区：
文献类型：
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作者：
Naar, Sylvie;Czajkowski, Susan M.;Spring, Bonnie
目的：改善饮食，活动水平和药物依从性以及控制烟草和其他物质的使用都已被证明可以在健康结果方面产生可衡量的，具有成本效益的改善。然而，许多人对现有的治疗没有反应，有效的干预措施往往没有大规模实施。在不同人群中开发和实施更有效的行为治疗，以最终改善公共卫生，涉及到跨转化谱的行为干预研究。很少有人关注早期试验的设计、方法和分析技术。方法：美国国立卫生研究院赞助了一个跨研究所，为期2天的创新研究设计和方法研讨会，用于开发，测试和实施行为干预措施，以改善健康，审查，评估和传播选择的创新设计和分析策略，用于行为干预研究。结果：组织研讨会是为了反映适用于整个翻译谱的方法。由于对随机临床试验的历史关注，研讨会特别强调了行为干预的设计和初步测试，干预措施的优化以及试验的后期有效性和实施。结论：本文总结了研讨会上讨论的方法，并建议使用这些方法来提高整个翻译范围内行为干预研究的影响，范围和成本效益。
Objective: Improving diet, activity level, and medication adherence and controlling tobacco and other substance use have all been shown to produce measurable, cost-effective improvements in health outcomes. However, many individuals do not respond to available treatments, and efficacious interventions are often not brought to scale. Developing and implementing more potent behavioral treatments in diverse populations to ultimately improve public health involves a focus on behavioral intervention research across the translational spectrum. There has been little attention paid to designs, methods, and analytic techniques for early phase trials. Method: The National Institutes of Health sponsored a cross-institute, 2-day Workshop on Innovative Study Designs and Methods for Developing, Testing and Implementing Behavioral Interventions to Improve Health to review, evaluate, and disseminate a selection of innovative designs and analytic strategies for use in behavioral intervention studies. Results: The workshop was organized to reflect methods appropriate for use across the translational spectrum. Because of the historical attention paid to the randomized clinical trial, the workshop placed particular emphasis on the designing and preliminary testing of behavioral interventions, the optimization of interventions, and the later effectiveness and implementation of trials. Conclusions: This article provides a summary of the methods discussed at the workshop, with recommendations for their use to improve the impact, reach, and cost-effectiveness of behavioral intervention research across the translational spectrum.