Developmental changes of the contingent negative variation in migraine and healthy children
Developmental changes of the contingent negative variation in migraine and healthy children
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DOI：
10.1007/s10194-009-0180-9
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发表时间：
2010-04-01
影响因子：
7.4
通讯作者：
Stephani, Ulrich
中科院分区：
文献类型：
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作者：
Siniatchkin, Michael;Jonas, Anne;Stephani, Ulrich
偏头痛的信息处理异常可能与大脑成熟障碍有关。然而，这一假设的大多数证据来自儿童时期的横断面研究。我们进行了一项纵向研究，并记录了1998年和8年后（2006年）偏头痛儿童（n = 27）和年龄匹配的健康个体（n = 23）的关联负变（CNV），一种事件相关的慢皮层电位。在观察时间内，所有CNV组分的振幅降低，初始CNV（iCNV）的习惯化增加。然而，iCNV振幅的降低在2006年缓解的偏头痛患者和健康受试者中更明显，而在持续头痛的偏头痛患者中不太明显。偏头痛恶化的患者在1998年表现出最明显的iCNV习惯性丧失，并在2006年显著增加了iCNV振幅。这项纵向研究支持偏头痛大脑成熟受损的假设，并表明偏头痛表现是干扰中枢信息处理自然成熟过程的关键因素。
It has been hypothesized that abnormalities of information processing in migraine may be attributed to impairment of cerebral maturation. However, the most evidences for this hypothesis have come from cross-sectional studies during childhood. We performed a longitudinal study and recorded contingent negative variation (CNV), an event-related slow cortical potential, in migraine children (n = 27) and age-matched healthy individuals (n = 23) in 1998 and 8 years later (2006). Amplitudes of all CNV components were reduced and habituation of the initial CNV (iCNV) increased in the observed time. However, the reduction of the iCNV amplitude was more pronounced in migraine patients who were in remission in 2006 and in healthy subjects and less pronounced in migraineurs with persisting headaches. Patients with the worsened migraine demonstrated the most pronounced loss of iCNV habituation in 1998 and significantly increased iCNV amplitudes in 2006. This longitudinal study supports the hypothesis of impaired cerebral maturation in migraine and shows that migraine manifestation is a key factor interfering with the natural maturation process of central information processing.