Mental health in Alberta grain farmers using pesticides over many years
Mental health in Alberta grain farmers using pesticides over many years
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DOI：
10.1093/occmed/kqs136
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发表时间：
2012-09-01
影响因子：
5.1
通讯作者：
Senthilselvan, A.
中科院分区：
文献类型：
--
作者：
Cherry, N.;Burstyn, I.;Senthilselvan, A.
有机磷和某些其他农药的暴露与精神疾病的症状有关。特别感兴趣的是多年暴露是否可能导致慢性疾病。目的将阿尔伯塔老年粮农的农药暴露史与精神疾病的症状和医疗记录联系起来。方法确定两个粮农群体进行研究：队列A（n = 5986），1983年阿尔伯塔农场组织的成员;队列B（n = 4781），在省农业部注册的谷物农民。在2002- 2003年，两组人都完成了一份关于农药使用史、医生诊断的疾病和最近神经心理症状的问卷。暴露于七种农药成分的持续时间进行了计算，并从症状问卷的回答中提取了一个因子得分。对于存活至2009年的子队列，确定了精神疾病的医疗记录。记录和症状评分与农药暴露允许confounding.Results从队列A，1348和队列B，1078人活着，接受采访（中位年龄63岁，中位持续时间在农业40年）：1371被链接到医疗记录数据库。精神疾病的症状评分与暴露于苯氧基化合物的持续时间（但不是其他农药）和精神疾病的医疗记录：那些精神疾病的出院记录更有可能已经暴露于苯氧基化合物为35 years.Conclusions长期暴露于苯氧基除草剂和神经精神症状的关系是出乎意料的，但不能解释测量的混杂因素。
Background Exposure to organophosphates and certain other pesticides has been related to symptoms of mental ill-health. There is particular interest in whether exposure over many years may result in chronic ill-health.Aims To relate lifetime history of pesticide exposure to symptoms and medical records of mental ill-health in elderly grain farmers in Alberta.Methods Two populations of grain farmers were identified for study: cohort A (n = 5986), members of an Alberta farm organization in 1983; cohort B (n = 4781), grain farmers registered with the provincial department of agriculture. In 2002-03 both groups completed a questionnaire on lifetime history of pesticide use, physician diagnosed disease and recent neuropsychological symptoms. Durations of exposure to seven pesticide components were calculated and a factor score extracted from responses to the symptom questionnaire. For a sub-cohort surviving to 2009 medical records for mental ill-health were identified. Records and symptom scores were related to pesticide exposures allowing for confounding.Results From cohort A, 1348 and cohort B, 1078 were alive and interviewed (median age 63 years; median duration in farming 40 years): 1371 were linked to the medical records database. Mental ill-health symptom scores were related to duration of exposure to phenoxy compounds (but not to other pesticides) and to mental ill-health in medical records:Those with mental ill-health in hospital discharge records were more likely to have been exposed to phenoxy compounds for 35 years.Conclusions The relationship of long-term exposure to phenoxy herbicides and neuropsychiatric symptoms was unexpected but not explained by measured confounders.