Thermogenesis mediated by a capsaicin‐sensitive area in the ventrolateral medulla
Thermogenesis mediated by a capsaicin‐sensitive area in the ventrolateral medulla
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延髓腹外侧辣椒素敏感区介导的生热作用
DOI：
10.1097/00001756-200008030-00017
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发表时间：
2000
期刊：
影响因子：
1.7
通讯作者：
S. Kimura
中科院分区：
文献类型：
--
作者：
T. Osaka;Tai;A. Kobayashi;S. Inoue;S. Kimura
辣椒素的全身管理引起产热，这可以观察到在脱焦制剂，但被脊髓横断阻断。为了确定辣椒素诱导的脑干产热的关键位点，我们研究了辣椒素对双侧交感肾上腺神经节前神经元运动前区电解损伤的影响。在吻侧腹外侧髓质（RVLM）的病变，而不是在其他区域，在很大程度上减弱了辣椒素诱导的热量产生。单侧微注射30-100 nl辣椒素（0.5%,w/v）进入RVLM可引起产热反应，而邻近区域注射辣椒素或车辆注射辣椒素对RVLM的产热没有影响。这些结果表明，辣椒素的产热作用至少部分是由RVLM中一些辣椒素敏感结构介导的。
Systemic administration of capsaicin elicits heat production, which can be observed in decerebrated preparations but is blocked by spinal transection. To identify the critical locus involved in the capsaicin-induced thermogenesis in the brainstem, we studied the effect of capsaicin on rats with bilateral electrolytic lesions in the premotor areas of sympathoadrenal preganglionic neurons. Lesions in the rostral ventrolateral medulla (RVLM), but not in other regions, largely attenuated the capsaicin-induced heat production. Unilateral microinjection of 30–100 nl capsaicin (0.5%, w/v) into the RVLM elicited a heat production response, whereas capsaicin injection in neighboring areas or vehicle injection into the RVLM did not affect heat production. These results suggest that the thermogenic effect of capsaicin is mediated, at least in part, by some capsaicin-sensitive structure in the RVLM.