Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms-Biomarkers-Interventions, and Future Perspectives.
Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms-Biomarkers-Interventions, and Future Perspectives.
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DOI：
10.1155/2017/6193694
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发表时间：
2017
影响因子：
--
通讯作者：
Dounousi E
中科院分区：
文献类型：
--
作者：
Pavlakou P;Liakopoulos V;Eleftheriadis T;Mitsis M;Dounousi E
急性肾损伤（AKI）是一种多因素疾病，发生于多种临床情况。虽然AKI并非入住重症监护病房（ICU）的常见原因，但它常常使重症患者的临床病程复杂化，需要肾脏替代治疗，有时会进展为终末期肾病并增加死亡率。ICU患者群体中AKI的病因因代谢状态受损、全身炎症、败血症和血流动力学失调而进一步复杂，导致产生氧化应激反应的失衡。大量实验数据以及较少的临床数据支持氧化应激相关机制在AKI损伤阶段的重要作用。本文的目的是介绍ICU患者中AKI的主要病理生理机制，重点关注氧化应激产生的不同方面、AKI预防干预措施的现有证据、临床环境中使用的生物标志物以及氧化应激调节的未来展望。
Acute kidney injury (AKI) is a multifactorial entity that occurs in a variety of clinical settings. Although AKI is not a usual reason for intensive care unit (ICU) admission, it often complicates critically ill patients' clinical course requiring renal replacement therapy progressing sometimes to end-stage renal disease and increasing mortality. The causes of AKI in the group of ICU patients are further complicated from damaged metabolic state, systemic inflammation, sepsis, and hemodynamic dysregulations, leading to an imbalance that generates oxidative stress response. Abundant experimental and to a less extent clinical data support the important role of oxidative stress-related mechanisms in the injury phase of AKI. The purpose of this article is to present the main pathophysiologic mechanisms of AKI in ICU patients focusing on the different aspects of oxidative stress generation, the available evidence of interventional measures for AKI prevention, biomarkers used in a clinical setting, and future perspectives in oxidative stress regulation.
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影响因子：
11.2
作者：
Chakraborty, Subhankar;Kaur, Sukhwinder;Guha, Sushovan;Batra, Surinder K.
通讯作者：
Batra, Surinder K.
影响因子：
6.1
作者：
Bagshaw, Sean M.;George, Carol;Bellomo, Rinaldo
通讯作者：
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影响因子：
5
作者：
Antus, Balazs;Drozdovszky, Orsolya;Kelemen, Krisztina
通讯作者：
Kelemen, Krisztina
DOI：
10.1159/000313738
发表时间：
2010-01-01
期刊：
CARDIORENAL SYNDROMES IN CRITICAL CARE
影响因子：
--
作者：
Bonventre, Joseph V.
通讯作者：
Bonventre, Joseph V.
影响因子：
6.2
作者：
Chien, Chiang-Ting;Shyue, Song-Kuen;Lai, Ming-Kuen
通讯作者：
Lai, Ming-Kuen