Arterial waveguide model for shear wave elastography: implementation and in vitro validation
Arterial waveguide model for shear wave elastography: implementation and in vitro validation
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DOI：
10.1088/1361-6560/aa6ee3
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发表时间：
2017-07-07
影响因子：
3.5
通讯作者：
Guddati, Murthy N.
中科院分区：
文献类型：
--
作者：
Astaneh, Ali Vaziri;Urban, Matthew W.;Guddati, Murthy N.
动脉僵硬度被认为是许多心血管疾病的早期指标。在各种技术中，剪切波弹性成像已经成为通过观察到的导波的分散来估计局部动脉硬度的有前途的工具。在本文中，我们开发了有效的模型在动脉壁中的导波色散的计算模拟。该模型能够考虑在体外/离体和体内实验中遇到的浸没在流体中或嵌入在固体中的流体加载管。所提出的方法是基于明智地结合傅立叶变换和有限元离散化，导致显着降低计算成本，同时充分捕捉复杂的三维波传播。所开发的方法在开源代码中实现，并通过与更昂贵的全三维有限元模型进行比较来验证。我们还验证了模型使用剪切波弹性成像的仿组织体模。所开发的方法的计算效率表明能够在真实的时间内估计动脉硬度的可能性，这在临床环境中将是有益的。
Arterial stiffness is found to be an early indicator of many cardiovascular diseases. Among various techniques, shear wave elastography has emerged as a promising tool for estimating local arterial stiffness through the observed dispersion of guided waves. In this paper, we develop efficient models for the computational simulation of guided wave dispersion in arterial walls. The models are capable of considering fluid-loaded tubes, immersed in fluid or embedded in a solid, which are encountered in in vitro/ex vivo, and in vivo experiments. The proposed methods are based on judiciously combining Fourier transformation and finite element discretization, leading to a significant reduction in computational cost while fully capturing complex 3D wave propagation. The developed methods are implemented in open-source code, and verified by comparing them with significantly more expensive, fully 3D finite element models. We also validate the models using the shear wave elastography of tissue-mimicking phantoms. The computational efficiency of the developed methods indicates the possibility of being able to estimate arterial stiffness in real time, which would be beneficial in clinical settings.